Noninvasive assessment of peripheral skeletal muscle weakness in idiopathic pulmonary fibrosis: a pilot study with multiparametric MRI of the rectus femoris muscle.

Autor: de Paula WD; Department of Radiology, Brasilia University Hospital, University of Brasilia., Rodrigues MP; Department of Pulmonology, Brasilia University Hospital, University of Brasilia, Brazil Institution where the work was done: Hospital Universitário de Brasília / Universidade de Brasília, Brazil., Ferreira NMC; Department of Pulmonology, Brasilia University Hospital, University of Brasilia, Brazil Institution where the work was done: Hospital Universitário de Brasília / Universidade de Brasília, Brazil., Passini VV; Department of Pulmonology, Brasilia University Hospital, University of Brasilia, Brazil Institution where the work was done: Hospital Universitário de Brasília / Universidade de Brasília, Brazil., Melo-Silva CA; Department of Pulmonology, Brasilia University Hospital, University of Brasilia, Brazil Institution where the work was done: Hospital Universitário de Brasília / Universidade de Brasília, Brazil.
Jazyk: angličtina
Zdroj: Multidisciplinary respiratory medicine [Multidiscip Respir Med] 2020 Nov 17; Vol. 15 (1), pp. 707. Date of Electronic Publication: 2020 Nov 17 (Print Publication: 2020).
DOI: 10.4081/mrm.2020.707
Abstrakt: Background: To investigate differences in magnetic resonance imaging (MRI) features of rectus femoris muscle between idiopathic pulmonary fibrosis (IPF) patients and healthy volunteers.
Methods: Thirteen IPF patients with GAP Index stage II disease were subjected to pulmonary function tests, 6-minute walk test (6MWT), quadriceps femoris muscle strength measurement and MRI of the thigh at rest. At MRI, muscle cross-sectional areas, T2 and T2* relaxometry, and 3-point Dixon fat fraction were measured. The results were compared to those of eight healthy sedentary volunteers.
Results: IPF patients had significantly lower %predicted FVC, FEV 1 and DL CO (p<0.001 for the three variables) and walked significantly less in the 6MWT (p=0.008). Mean quadriceps femoris muscle strength also was significantly lower in IPF patients (p=0.041). Rectus femoris muscle T2* measurements were significantly shorter in IPF patients (p=0.027). No significant intergroup difference was found regarding average muscle cross-sectional areas (p=0.790 for quadriceps and p=0.816 for rectus femoris) or rectus femoris fat fraction (p=0.901). Rectus femoris T2 values showed a non-significant trend to be shorter in IPF patients (p=0.055).
Conclusions: Our preliminary findings suggest that, besides disuse atrophy, other factors such as hypoxia (but not inflammation) may play a role in the peripheral skeletal muscle dysfunction observed in IPF patients. This might impact the rehabilitation strategies for IPF patients and warrants further investigation.
(©Copyright: the Author(s).)
Databáze: MEDLINE
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