A novel streptonigrin type alkaloid from the Streptomyces flocculus CGMCC 4.1223 mutant Δ stnA/Q2 .

Autor:	Wang X; State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory on Metabolic & Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, China., Xu F; School of Medicine, Zhejiang University, Hangzhou, China., Huang T; State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory on Metabolic & Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, China., Deng Z; State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory on Metabolic & Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, China., Lin S; State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory on Metabolic & Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Jazyk:	angličtina
Zdroj:	Natural product research [Nat Prod Res] 2022 Jul; Vol. 36 (13), pp. 3337-3345. Date of Electronic Publication: 2020 Dec 07.
DOI:	10.1080/14786419.2020.1856840
Abstrakt:	Streptonigrin (STN) is a highly functionalized aminoquinone alkaloid with broad and potent antitumor activities. Previously, the biosynthetic gene cluster of STN was identified in Streptomyces flocculus CGMCC 4.1223, revealing an α/β-hydrolase (StnA) and a methyltransferase (StnQ2). In this work, a double mutant Δ stnA/Q2 was constructed by genetic manipulation and produced a novel derivative of STN, named as streptonigramide. Structure of streptonigramide was established by spectroscopic analyses. Its biosynthetic pathway has been proposed as well.
Databáze:	MEDLINE
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