Laser Treatment of Pancreatic Cancer with Immunostimulating Interstitial Laser Thermotherapy Protocol: Safety and Feasibility Results From Two Phase 2a Studies.

Autor: Paiella S; General and Pancreatic Surgery Unit, Pancreas Institute, University of Verona, Verona, Italy. Electronic address: salvatore.paiella@univr.it., Casetti L; General and Pancreatic Surgery Unit, Pancreas Institute, University of Verona, Verona, Italy., Ewald J; Department of Surgery, Aix-Marseille University, Institut Paoli-Calmettes, CNRS, Inserm, CRCM, Marseille, France., Marchese U; Department of Surgery, Aix-Marseille University, Institut Paoli-Calmettes, CNRS, Inserm, CRCM, Marseille, France., D'Onofrio M; Department of Radiology, Pancreas Institute, University of Verona, Verona, Italy., Garnier J; Department of Surgery, Aix-Marseille University, Institut Paoli-Calmettes, CNRS, Inserm, CRCM, Marseille, France., Landoni L; General and Pancreatic Surgery Unit, Pancreas Institute, University of Verona, Verona, Italy., Gilabert M; Department of Oncology, Institut Paoli-Calmettes, Marseille, France., Manzini G; General and Pancreatic Surgery Unit, Pancreas Institute, University of Verona, Verona, Italy., Esposito A; General and Pancreatic Surgery Unit, Pancreas Institute, University of Verona, Verona, Italy., Secchettin E; General and Pancreatic Surgery Unit, Pancreas Institute, University of Verona, Verona, Italy., Malleo G; General and Pancreatic Surgery Unit, Pancreas Institute, University of Verona, Verona, Italy., Lionetto G; General and Pancreatic Surgery Unit, Pancreas Institute, University of Verona, Verona, Italy., De Pastena M; General and Pancreatic Surgery Unit, Pancreas Institute, University of Verona, Verona, Italy., Bassi C; General and Pancreatic Surgery Unit, Pancreas Institute, University of Verona, Verona, Italy., Delpero JR; Department of Surgery, Aix-Marseille University, Institut Paoli-Calmettes, CNRS, Inserm, CRCM, Marseille, France., Salvia R; General and Pancreatic Surgery Unit, Pancreas Institute, University of Verona, Verona, Italy., Turrini O; Department of Surgery, Aix-Marseille University, Institut Paoli-Calmettes, CNRS, Inserm, CRCM, Marseille, France.
Jazyk: angličtina
Zdroj: The Journal of surgical research [J Surg Res] 2021 Mar; Vol. 259, pp. 1-7. Date of Electronic Publication: 2020 Dec 02.
DOI: 10.1016/j.jss.2020.10.027
Abstrakt: Purpose: Ablative techniques have emerged as new potential therapeutic options for patients with locally advanced pancreatic cancer (LAPC). We explored the safety and feasibility of using TRANBERG|Thermal Therapy System (Clinical Laserthermia Systems AB, Lund, Sweden) in feedback mode for immunostimulating Interstitial Laser Thermotherapy (imILT) protocol, the newest ablative technique introduced for the treatment of LAPC.
Methods: The safety and feasibility results after the use of imILT protocol treatment in 15 patients of a prospective series of postsystemic therapy LAPC in two high-volume European institutions, the General and Pancreatic Unit of the Pancreas Institute, of the University of Verona, Italy, and the Department of Surgical Oncology of the Institut Paoli-Calmettes of Marseille, France, were assessed.
Results: The mean age was 66 ± 5 years, with a mean tumor size of 34.6 (±8) mm. The median number of cycles of pre-imILT chemotherapy was 6 (6-12). The procedure was performed in 13 of 15 (86.6%) cases; indeed, in two cases, the procedure was not performed; in one, the procedure was considered technically demanding; in the other, liver metastases were found intraoperatively. In all treated cases, the procedure was completed. Three late pancreatic fistulas developed over four overall adverse events (26.6%) and were attributed to imILT. Mortality was nil. A learning curve is necessary to interpret and manage the laser parameters.
Conclusions: Safety, feasibility, and device handling outcomes of using TRANBERG|Thermal Therapy System with temperature probes in feedback mode and imILT protocol on LAPC were not satisfactory. The metastatic setting may be appropriate to evaluate the hypothetic abscopal effect.#NCT02702986 and #NCT02973217.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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