Dynamics of androgens in healthy and hospitalized newborn foals.

Autor: Swink JM; College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA., Rings LM; College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA.; Rood and Riddle Equine Hospital, Lexington, Kentucky, USA., Snyder HA; College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA., McAuley RC; College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA., Burns TA; College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA., Dembek KA; College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA., Gilsenan WF; Rood and Riddle Equine Hospital, Lexington, Kentucky, USA., Browne N; Hagyard Equine Medical Institute, Lexington, Kentucky, USA., Toribio RE; College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA.
Jazyk: angličtina
Zdroj: Journal of veterinary internal medicine [J Vet Intern Med] 2021 Jan; Vol. 35 (1), pp. 538-549. Date of Electronic Publication: 2020 Dec 05.
DOI: 10.1111/jvim.15974
Abstrakt: Background: Information on steroids derived from the adrenal glands, gonads, or fetoplacental unit is minimal in newborn foals.
Objective: To measure androgen concentrations in serum and determine their association with disease severity and outcome in hospitalized foals.
Animals: Hospitalized (n = 145) and healthy (n = 80) foals.
Methods: Prospective, multicenter, cross-sectional study. Foals of ≤3 days of age from 3 hospitals and horse farms were classified as healthy and hospitalized (septic, sick nonseptic, neonatal maladjustment syndrome [NMS]) based on physical exam, medical history, and laboratory findings. Serum androgen and plasma ACTH concentrations were measured with immunoassays. Data were analyzed by nonparametric methods and univariate analysis.
Results: Serum dehydroepiandrosterone (DHEA), androstenedione, testosterone, and dihydrotestosterone (DHT) concentrations were higher upon admission in hospitalized foals (P <  .05), were associated with nonsurvival, decreased to 4.9-10.8%, 5.7-31%, and 30.8-62.8% admission values in healthy, SNS, and septic foals, respectively (P < .05), but remained unchanged or increased in nonsurviving foals. ACTH:androgen ratios were higher in septic and NMS foals (P < .05). Foals with decreased androgen clearance were more likely to die (odds ratio > 3; P < .05).
Conclusions and Clinical Importance: Similar to glucocorticoids, mineralocorticoids, and progestagens, increased serum concentrations of androgens are associated with disease severity and adverse outcome in hospitalized newborn foals. In healthy foals, androgens decrease over time, however, remain elevated longer in septic and nonsurviving foals. Androgens could play a role in or reflect a response to disorders such as sepsis or NMS in newborn foals.
(© 2020 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.)
Databáze: MEDLINE
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