Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.

Autor:	Volz E; MRC Centre for Global Infectious Disease Analysis, School of Public Health, Imperial College London, London, UK. Electronic address: e.volz@imperial.ac.uk., Hill V; Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK., McCrone JT; Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK., Price A; School of Biosciences, Cardiff University, Cardiff, UK., Jorgensen D; MRC Centre for Global Infectious Disease Analysis, School of Public Health, Imperial College London, London, UK., O'Toole Á; Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK., Southgate J; School of Biosciences, Cardiff University, Cardiff, UK; Pathogen Genomics Unit, Public Health Wales NHS Trust, Cardiff, UK., Johnson R; MRC Centre for Global Infectious Disease Analysis, School of Public Health, Imperial College London, London, UK., Jackson B; Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK., Nascimento FF; MRC Centre for Global Infectious Disease Analysis, School of Public Health, Imperial College London, London, UK., Rey SM; Pathogen Genomics Unit, Public Health Wales NHS Trust, Cardiff, UK., Nicholls SM; Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK., Colquhoun RM; Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK., da Silva Filipe A; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK., Shepherd J; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK., Pascall DJ; Institute of Biodiversity, Animal Health and Comparative Medicine, Boyd Orr Centre for Population and Ecosystem Health, University of Glasgow, Glasgow, UK., Shah R; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK., Jesudason N; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK., Li K; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK., Jarrett R; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK., Pacchiarini N; Pathogen Genomics Unit, Public Health Wales NHS Trust, Cardiff, UK., Bull M; Pathogen Genomics Unit, Public Health Wales NHS Trust, Cardiff, UK., Geidelberg L; MRC Centre for Global Infectious Disease Analysis, School of Public Health, Imperial College London, London, UK., Siveroni I; MRC Centre for Global Infectious Disease Analysis, School of Public Health, Imperial College London, London, UK., Goodfellow I; Department of Pathology, University of Cambridge, Cambridge, UK., Loman NJ; Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK., Pybus OG; Department of Zoology, University of Oxford, Oxford, UK; Department of Pathobiology and Population Sciences, The Royal Veterinary College, London, UK., Robertson DL; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK., Thomson EC; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK., Rambaut A; Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK. Electronic address: a.rambaut@ed.ac.uk., Connor TR; School of Biosciences, Cardiff University, Cardiff, UK; Pathogen Genomics Unit, Public Health Wales NHS Trust, Cardiff, UK; Quadram Institute Bioscience, Norwich, UK. Electronic address: connortr@cardiff.ac.uk.
Jazyk:	angličtina
Zdroj:	Cell [Cell] 2021 Jan 07; Vol. 184 (1), pp. 64-75.e11. Date of Electronic Publication: 2020 Nov 19.
DOI:	10.1016/j.cell.2020.11.020
Abstrakt:	Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant. Competing Interests: Declaration of Interests The authors declare no competing interests. (Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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