Effects of selenium supplementation on pregnancy outcomes and disease progression in HIV-infected pregnant women in Lagos: A randomized controlled trial.

Autor: Okunade KS; Department of Obstetrics and Gynecology, College of Medicine, University of Lagos, Lagos, Nigeria.; Department of Obstetrics and Gynecology, Lagos University Teaching Hospital, Lagos, Nigeria., Olowoselu OF; Department of Hematology and Blood Transfusion, College of Medicine, University of Lagos, Lagos, Nigeria., John-Olabode S; Department of Hematology and Blood Transfusion, College of Medicine, University of Lagos, Lagos, Nigeria., Hassan BO; AIDS Prevention Initiative in Nigeria (APIN) Clinic, Lagos University Teaching Hospital, Lagos, Nigeria., Akinsola OJ; Department of Community Health and Primary Health Care, College of Medicine, University of Lagos, Lagos, Nigeria., Nwogu CM; Department of Obstetrics and Gynecology, Lagos University Teaching Hospital, Lagos, Nigeria., Ugwu AO; Department of Obstetrics and Gynecology, Lagos University Teaching Hospital, Lagos, Nigeria., Moses OE; Department of Obstetrics and Gynecology, Lagos State University Teaching Hospital, Ikeja, Nigeria., Rabiu KA; Department of Obstetrics and Gynecology, Lagos State University Teaching Hospital, Ikeja, Nigeria., Ajepe A; Department of Obstetrics and Gynecology, Lagos University Teaching Hospital, Lagos, Nigeria., Adenekan MA; Department of Obstetrics and Gynecology, Lagos University Teaching Hospital, Lagos, Nigeria., Adejimi AA; Department of Community Health and Primary Health Care, College of Medicine, University of Lagos, Lagos, Nigeria., Akanmu SA; Department of Hematology and Blood Transfusion, College of Medicine, University of Lagos, Lagos, Nigeria., Kanki PJ; Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA.
Jazyk: angličtina
Zdroj: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics [Int J Gynaecol Obstet] 2021 Jun; Vol. 153 (3), pp. 533-541. Date of Electronic Publication: 2021 Jan 05.
DOI: 10.1002/ijgo.13514
Abstrakt: Objective: To examine the effects of selenium supplementation on pregnancy outcomes and disease progression among HIV-infected pregnant women in Lagos.
Methods: A randomized, placebo-controlled trial conducted among HIV-positive pregnant women between September 2018 and August 2019. At enrollment, 90 women were randomly assigned into each treatment arm to receive either a daily tablet of 200 μg elemental selenium or a placebo. Relevant participants' sociodemographic and clinical data were collected at enrollment and delivery.
Results: Women in the selenium arm had a significantly lower risk of preterm delivery (relative risk [RR] 0.32, 95% confidence interval [CI] 0.11-0.96) and a non-significant reduction in the risk of delivering term neonates with a low delivery weight (RR 0.24, 95% CI 0.05-1.19). Supplemental selenium does not increase the risk of perinatal death and adverse drug events.
Conclusion: The study reported a beneficial effect of prenatal selenium supplements on the risk of preterm delivery with no further reduction in risk among HIV-infected women who used the supplements for more than 14 weeks.
Trial Registration: Pan African Clinical Trial Registry (PACTR201809756724274).
(© 2020 International Federation of Gynecology and Obstetrics.)
Databáze: MEDLINE
Externí odkaz: