Peanut-induced anaphylaxis in children and adolescents: Data from the European Anaphylaxis Registry.

Autor: Maris I; Bon Secours Hospital Cork/Paediatrics and Child Health, University College Cork, Cork, Ireland., Dölle-Bierke S; Division of Allergy and Immunology, Department of Dermatology, Venereology and Allergology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Renaudin JM; Allergy Vigilance Network, Vandoeuvre les Nancy, France., Lange L; Department of Paediatrics, St. Marien-Hospital, Bonn, Germany., Koehli A; Division of Allergology, University Children's Hospital Zurich, Zürich, Switzerland., Spindler T; Department of Paediatrics, Medical Campus Hochgebirgsklinik Davos, Davos, Switzerland., Hourihane J; Paediatrics and Child Health, Royal College of Surgeons in Ireland, Dublin, Ireland.; Children's Health Ireland, Dublin, Ireland., Scherer K; Medical Faculty, University of Basel, Basel, Switzerland., Nemat K; Practice for paediatric pneumology and allergology, Kinderzentrum Dresden-Friedrichstadt, Dresden, Germany., Kemen C; Department of Paediatrics, Children's Hospital WILHELMSTIFT, Hamburg, Germany., Neustädter I; Department of Paediatrics, Hallerwiese Cnopfsche Kinderklinik, Nuremberg, Germany., Vogelberg C; Department of Paediatrics, Universitätsklinikum Carl Gustav Carus, Technical University, Dresden, Germany., Reese T; Department of Paediatrics, Mathias-Spital Rheine, Rheine, Germany., Yildiz I; Department of Paediatrics, Friedrich-Ebert-Krankenhaus, Neumuenster, Germany., Szepfalusi Z; Division of Paediatric Pulmonology, Allergology and Endocrinology, Department of Paediatrics and Adolescent Medicine, Competence Center Paediatrics, Medical University of Vienna, Vienna, Austria., Ott H; Division of Paediatric Dermatology and Allergology, Epidermolysis bullosa-Centre Hannover, Children's Hospital AUF DER BULT, Hanover, Germany., Straube H; Division of Allergology, Darmstädter Kinderkliniken Prinzessin Margaret, Darmstadt, Germany., Papadopoulos NG; Allergy Department, 2nd Paediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.; Division of Infection, Immunity& Respiratory Medicine, University of Manchester, Manchester, UK., Hämmerling S; Division of Paediatric Pulmonology and Allergology, University Children`s Hospital Heidelberg, Heidelberg, Germany., Staden U; Paediatric Pneumology & Allergology, Medical practice Klettke/Staden, Berlin, Germany., Polz M; Department of Paediatrics, GPR Klinikum, Rüsselsheim, Germany., Mustakov T; Chair of Allergy, University Hospital Alexandrovska, Sofia, Bulgaria., Cichocka-Jarosz E; Department of Paediatrics, Jagiellonian University Medical College, Krakow, Poland., Cocco R; Division of Allergy, Clinical Immunology and Rheumatology, Department of Paediatrics, Federal University of São Paulo, São Paulo, Brazil., Fiocchi AG; Paediatric Hospital Bambino Gesù IRCCS, Rome, Holy See., Fernandez-Rivas M; Allergy Department, Hospital Clinico San Carlos, Universidad Complutense, IdISSC, ARADyAL, Madrid, Spain., Worm M; Division of Allergy and Immunology, Department of Dermatology, Venereology and Allergology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Jazyk: angličtina
Zdroj: Allergy [Allergy] 2021 May; Vol. 76 (5), pp. 1517-1527. Date of Electronic Publication: 2021 Jan 03.
DOI: 10.1111/all.14683
Abstrakt: Background: Peanut allergy has a rising prevalence in high-income countries, affecting 0.5%-1.4% of children. This study aimed to better understand peanut anaphylaxis in comparison to anaphylaxis to other food triggers in European children and adolescents.
Methods: Data was sourced from the European Anaphylaxis Registry via an online questionnaire, after in-depth review of food-induced anaphylaxis cases in a tertiary paediatric allergy centre.
Results: 3514 cases of food anaphylaxis were reported between July 2007 - March 2018, 56% in patients younger than 18 years. Peanut anaphylaxis was recorded in 459 children and adolescents (85% of all peanut anaphylaxis cases). Previous reactions (42% vs. 38%; p = .001), asthma comorbidity (47% vs. 35%; p < .001), relevant cofactors (29% vs. 22%; p = .004) and biphasic reactions (10% vs. 4%; p = .001) were more commonly reported in peanut anaphylaxis. Most cases were labelled as severe anaphylaxis (Ring&Messmer grade III 65% vs. 56% and grade IV 1.1% vs. 0.9%; p = .001). Self-administration of intramuscular adrenaline was low (17% vs. 15%), professional adrenaline administration was higher in non-peanut food anaphylaxis (34% vs. 26%; p = .003). Hospitalization was higher for peanut anaphylaxis (67% vs. 54%; p = .004).
Conclusions: The European Anaphylaxis Registry data confirmed peanut as one of the major causes of severe, potentially life-threatening allergic reactions in European children, with some characteristic features e.g., presence of asthma comorbidity and increased rate of biphasic reactions. Usage of intramuscular adrenaline as first-line treatment is low and needs to be improved. The Registry, designed as the largest database on anaphylaxis, allows continuous assessment of this condition.
(© 2021 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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