Brucellosis in Saudi Children: Presentation, Complications, and Treatment Outcome.

Autor:	Qasim SS; Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, SAU., Alshuwaier K; Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, SAU., Alosaimi MQ; Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, SAU., Alghafees MA; Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, SAU., Alrasheed A; Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, SAU., Layqah L; Pharmacy, King Abdullah International Medical Research Center, Riyadh, SAU., Baharoon S; Internal Medicine, King Abdulaziz Medical City Riyadh, Riyadh, SAU.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2020 Nov 01; Vol. 12 (11), pp. e11289. Date of Electronic Publication: 2020 Nov 01.
DOI:	10.7759/cureus.11289
Abstrakt:	Background Brucellosis, an endemic disease in Saudi Arabia, has an infection rate of 70 per 100,000 people, with a varying morbidity rate in different parts of the country. The aim of this study was to assess the epidemiological and clinical features, laboratory findings, treatment modalities, complications, and outcomes in children with brucellosis. Materials and methods The medical records of 153 patients attending King Abdullah Specialist Children's Hospital in Riyadh, Saudi Arabia, from January 2015 to January 2019 were reviewed retrospectively. Demographic data, laboratory test results, serum agglutination test titer, and the results of the blood cultures were obtained. The diagnosis of brucellosis was based on compatible signs and symptoms with a positive serology titer of ≥1:160 or a blood culture positive for Brucella species. Results The majority of the sample (69.6%, n=107) were males, with a mean age of 7.75 ± 3.28 years. Ingestion of unpasteurized camel dairy products was the most frequent transmission risk factor. The most prevalent presenting symptoms were constitutional and musculoskeletal symptoms. Six patients (3.9%) had complicated brucellosis, with neurobrucellosis diagnosed in three cases. Hospitalization for brucellosis was required in 15% of the patients. The majority (99.35%, n=152) of the patients had a serum agglutination test (SAT) titer of ≥1:160. A blood culture was positive in 52 (34%) of the 111 patients tested. The most frequently prescribed regimen was rifampicin + co-trimoxazole in 81 (52.9%) patients. Relapse occurred in a small proportion (4.6%, n=7), and the majority (95.4%, n=146) had a complete remission. Conclusions The main route of transmission was the ingestion of unpasteurized dairy products. Brucellosis had a wide range of clinical presentation, involving multiple organ systems. Neurobrucellosis was the most frequent complication. The SAT was the most useful and reliable test for the diagnosis of brucellosis. Most patients were successfully treated with rifampicin and co-trimoxazole for six weeks. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2020, Qasim et al.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu