Central systolic blood pressure relates inversely to nitric oxide synthesis in young black adults: the African-PREDICT study.

Autor: Craig A; Hypertension in Africa Research Team (HART); North-West University, Potchefstroom, South Africa., M C Mels C; Hypertension in Africa Research Team (HART); North-West University, Potchefstroom, South Africa.; MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa., Tsikas D; Institute of Toxicology, Core Unit Proteomics, Hannover Medical School, Hannover, Germany., Boeger RH; Institute of Clinical Pharmacology and Toxicology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany., Schwedhelm E; Institute of Clinical Pharmacology and Toxicology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.; Deutsches Zentrum fuer Herz-Kreislauf-Forschung E.V. (DZHK), Partner Site Hamburg/Kiel/Luebeck, Hamburg, Germany., Schutte AE; Hypertension in Africa Research Team (HART); North-West University, Potchefstroom, South Africa.; MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa.; School of Population Health, University of New South Wales; The George Institute for Global Health, Sydney, Australia., Kruger R; Hypertension in Africa Research Team (HART); North-West University, Potchefstroom, South Africa. ruan.kruger@g.nwu.ac.za.; MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa. ruan.kruger@g.nwu.ac.za.
Jazyk: angličtina
Zdroj: Journal of human hypertension [J Hum Hypertens] 2021 Nov; Vol. 35 (11), pp. 985-993. Date of Electronic Publication: 2020 Dec 03.
DOI: 10.1038/s41371-020-00453-9
Abstrakt: Lower nitric oxide (NO) bioavailabilty associates with hypertension in patients and elderly populations. With hypertension known to develop earlier in black populations, we compared both plasma and urinary NO-related markers and their associations with central systolic blood pressure (cSBP) and arterial stiffness in healthy young black and white adults. We included healthy black and white men and women (n = 1110; 20-30 years) and measured cSBP and pulse wave velocity (PWV), along with both plasma and urinary arginine, homoarginine, asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), as well as urinary ornithine/citrulline, nitrite and nitrate. In addition, the urinary nitrate-to-nitrite ratio (U NOx R) was calculated. The black men and women had higher cSBP and higher plasma arginine and ADMA, but lower urinary nitrate and U NOx R (all p ≤ 0.003) than their white counterparts. In single and forward stepwise multiple regression analyses, we found an inverse association of cSBP (adj. R 2  = 0.124; β = -0.134; p = 0.006) and plasma homoarginine in black men. Central SBP associated inversely with U NOx R in black women only (adj. R 2  = 0.171; β = -0.130; p = 0.029). In the white women, cSBP associated positively with urinary ADMA (adj. R 2  = 0.372; β = 0.162; p = 0.015). PWV associated inversely with plasma ADMA (adj. R 2  = 0.253; β = -0.163; p = 0.024) in the white women only. The lower NO synthesis and the higher cSBP in our black cohort support the notion of a potential increased risk for future large artery stiffness and hypertension development in later life.
(© 2020. The Author(s), under exclusive licence to Springer Nature Limited part of Springer Nature.)
Databáze: MEDLINE
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