Comparing the benefits of different radiological follow-up modalities in surgically resected non-small cell lung cancer (NSCLC). A single centre study, Leeds-UK.

Autor: Salman DR; St James hospital, Beckett St, Leeds, LS9 7TF, UK. Electronic address: Rashad.salman@nhs.net., Littlejohns DA; St James hospital, Beckett St, Leeds, LS9 7TF, UK. Electronic address: anna.littlejohns@nhs.net., Quinn DT; St James hospital, Beckett St, Leeds, LS9 7TF, UK. Electronic address: thomas.quinn@nhs.net., Campbell DC; St James hospital, Beckett St, Leeds, LS9 7TF, UK. Electronic address: catherine.campbell3@nhs.net., Robson DJ; St James hospital, Beckett St, Leeds, LS9 7TF, UK. Electronic address: jonathan.robson2@nhs.net.
Jazyk: angličtina
Zdroj: Cancer treatment and research communications [Cancer Treat Res Commun] 2020; Vol. 25, pp. 100252. Date of Electronic Publication: 2020 Nov 28.
DOI: 10.1016/j.ctarc.2020.100252
Abstrakt: Introduction: Computerised Tomography (CT) scans have been proposed as a potentially superior modality compared with chest x-rays in the follow up of lung cancer patients. In 2014 our Trust introduced a survivorship programme that included routine CT scans. This study is designed to assess the impact of this programme on the rate of recurrence, the treatment intent of recurrence and overall survival.
Materials and Methods: This was a retrospective review of 220 patients with surgically resected Stage I-III Non-Small Cell Lung Cancer (NSCLC). Data were collected for all patients treated in 2012 and 2013 that received chest x-ray follow up (Group A) and patients treated in 2015 that received CT scan based follow up (Group B).
Results: The rate of recurrence was similar between the two groups (31% vs 29%). Group B had a trend towards increased radical treatment of recurrence but this was not statistically significant (33% vs 47%); χ² (1,N = 66)=1.24, P = 0.27. Group B also had an increased mean overall survival (30.8 months ±0.8 months (95% CI 29.2- 32.4 months) vs 34.1 months ±0.7 months (95% CI 32.8-35.5 months)); log Rank=6.3, P = 0.01.
Conclusions: This study showed a trend towards a higher rate of radical treatment for recurrence in the CT follow up group, which may suggest a possible advantage of CT scans over plain radiographs. However, the results should be interpreted with caution given potential confounders. Importantly, Group B had larger proportion of Stage I disease and nationwide there was an improvement in lung cancer outcomes. Overall this remains an interesting area of study.
(Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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