Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of Aspergillus and Penicillium Genera.

Autor: Girich EV; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 690950 Vladivostok, Russia., Yurchenko AN; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 690950 Vladivostok, Russia., Smetanina OF; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 690950 Vladivostok, Russia., Trinh PTH; Department of Marine Biotechnology, Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, Nha Trang 650000, Vietnam., Ngoc NTD; Department of Marine Biotechnology, Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, Nha Trang 650000, Vietnam., Pivkin MV; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 690950 Vladivostok, Russia., Popov RS; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 690950 Vladivostok, Russia., Pislyagin EA; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 690950 Vladivostok, Russia., Menchinskaya ES; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 690950 Vladivostok, Russia., Chingizova EA; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 690950 Vladivostok, Russia., Afiyatullov SS; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 690950 Vladivostok, Russia., Yurchenko EA; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 690950 Vladivostok, Russia.
Jazyk: angličtina
Zdroj: Marine drugs [Mar Drugs] 2020 Nov 30; Vol. 18 (12). Date of Electronic Publication: 2020 Nov 30.
DOI: 10.3390/md18120608
Abstrakt: Low molecular weight secondary metabolites of marine fungi Aspergillus flocculosus , Aspergillus terreus and Penicillium sp. from Van Phong and Nha Trang Bays (Vietnam) were studied and a number of polyketides, bis-indole quinones and terpenoids were isolated. The structures of the isolated compounds were determined by 1D and 2D NMR and HR-ESI-MS techniques. Stereochemistry of some compounds was established based on ECD data. A chemical structure of asterriquinone F ( 6 ) was thoroughly described for the first time. Anthraquinone ( 13 ) was firstly obtained from a natural source. Neuroprotective influences of the isolated compounds against 6-OHDA, paraquat and rotenone toxicity were investigated. 4-Hydroxyscytalone ( 1 ), 4-hydroxy-6-dehydroxyscytalone ( 2 ) and demethylcitreoviranol ( 3 ) have shown significant increasing of paraquat- and rotenone-treated Neuro-2a cell viability and anti-ROS activity.
Databáze: MEDLINE