Fabrication of Infrared-Compatible Nanofluidic Devices for Plasmon-Enhanced Infrared Absorption Spectroscopy.

Autor: Le THH; Department of Applied Chemistry, Graduate School of Engineering, The University of Tokyo, Tokyo 113-8654, Japan., Matsushita T; Department of Applied Chemistry, Graduate School of Engineering, The University of Tokyo, Tokyo 113-8654, Japan., Ohta R; Collaborative Research Organization for Micro and Nano Multifunctional Devices (NMfD), The University of Tokyo, Tokyo 113-8654, Japan., Shimoda Y; Department of Bioengineering/Electrical Engineering and Information systems, Graduate School of Engineering, The University of Tokyo, Tokyo 113-8654, Japan., Matsui H; Department of Bioengineering/Electrical Engineering and Information systems, Graduate School of Engineering, The University of Tokyo, Tokyo 113-8654, Japan., Kitamori T; Collaborative Research Organization for Micro and Nano Multifunctional Devices (NMfD), The University of Tokyo, Tokyo 113-8654, Japan.; Institute of Nanoengineering and Microsystems iNEMS, Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu 300044, Taiwan.
Jazyk: angličtina
Zdroj: Micromachines [Micromachines (Basel)] 2020 Nov 30; Vol. 11 (12). Date of Electronic Publication: 2020 Nov 30.
DOI: 10.3390/mi11121062
Abstrakt: Nanofluidic devices have offered us fascinating analytical platforms for chemical and bioanalysis by exploiting unique properties of liquids and molecules confined in nanospaces. The increasing interests in nanofluidic analytical devices have triggered the development of new robust and sensitive detection techniques, especially label-free ones. IR absorption spectroscopy is one of the most powerful biochemical analysis methods for identification and quantitative measurement of chemical species in the label-free and non-invasive fashion. However, the low sensitivity and the difficulties in fabrication of IR-compatible nanofluidic devices are major obstacles that restrict the applications of IR spectroscopy in nanofluidics. Here, we realized the bonding of CaF 2 and SiO 2 at room temperature and demonstrated an IR-compatible nanofluidic device that allowed the IR spectroscopy in a wide range of mid-IR regime. We also performed the integration of metal-insulator-metal perfect absorber metamaterials into nanofluidic devices for plasmon-enhanced infrared absorption spectroscopy with ultrahigh sensitivity. This study also shows a proof-of-concept of the multi-band absorber by combining different types of nanostructures. The results indicate the potential of implementing metamaterials in tracking several characteristic molecular vibrational modes simultaneously, making it possible to identify molecular species in mixture or complex biological entities.
Databáze: MEDLINE
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