| Autor: |
Flipse J; Laboratory of Medical Microbiology and Infectious Diseases, Isala Clinics, 8025 AB Zwolle, The Netherlands., Duim B; Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands.; WHO Collaborating Center for Campylobacter/OIE Reference Laboratory for Campylobacteriosis, 3584 CL Utrecht, The Netherlands., Wallinga JA; Laboratory of Medical Microbiology and Infectious Diseases, Isala Clinics, 8025 AB Zwolle, The Netherlands., de Wijkerslooth LRH; Department of Gastroenterology & Hepatology, Isala Clinics, 8025 AB Zwolle, The Netherlands., Graaf-van Bloois LV; Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands.; WHO Collaborating Center for Campylobacter/OIE Reference Laboratory for Campylobacteriosis, 3584 CL Utrecht, The Netherlands., Timmerman AJ; Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands.; WHO Collaborating Center for Campylobacter/OIE Reference Laboratory for Campylobacteriosis, 3584 CL Utrecht, The Netherlands., Zomer AL; Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands.; WHO Collaborating Center for Campylobacter/OIE Reference Laboratory for Campylobacteriosis, 3584 CL Utrecht, The Netherlands., Veldman KT; Wageningen Bioveterinary Research, 8221 RA Lelystad, The Netherlands., Wagenaar JA; Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands.; WHO Collaborating Center for Campylobacter/OIE Reference Laboratory for Campylobacteriosis, 3584 CL Utrecht, The Netherlands.; Wageningen Bioveterinary Research, 8221 RA Lelystad, The Netherlands., Bloembergen P; Laboratory of Medical Microbiology and Infectious Diseases, Isala Clinics, 8025 AB Zwolle, The Netherlands. |
| Abstrakt: |
A man with a well-controlled HIV infection, previously diagnosed with lymphogranuloma venereum and treated for Hodgkin's lymphoma, was suffering from chronic diarrhea. He travelled to Indonesia in the month prior to the start of complaints. Over a 15-month period, sequences related to Campylobacter troglodytis/upsaliensis , C. pinnepediorum/mucosalis/concisus and C. hominis were detected by 16S rRNA qPCR-based assays in various stool samples and in a colon biopsy. Culture revealed the first isolation of " candidatus Campylobacter infans ", a species identified recently by molecular methods only. The patient was treated with azithromycin, ciprofloxacin and tetracycline. To identify potential continuous exposure of the patient to Campylobacter , stool samples of the partner and the cat of the patient were analyzed and C. pinnepediorum/mucosalis/concisus and C. helveticus , respectively, were detected. The diversity in detected species in this immunocompromised patient with a lack of repeatedly consistent findings resulted in the conclusion that not any of the Campylobacter species was the primary cause of the clinical condition. This study shows the challenges in detection and interpretation of diagnostic results regarding Campylobacter . |
