Exercise and Prediabetes after Renal Transplantation (EXPRED): Protocol Description.

Autor:	Morales Febles R; Faculty of Medicine, University of La Laguna, Tenerife, Spain.; UCICEC (Unidad Central de Investigación Clínica y Ensayos Clínicos), Research Unit, Hospital Universitario de Canarias, La Laguna, Spain., Negrín Mena N; UCICEC (Unidad Central de Investigación Clínica y Ensayos Clínicos), Research Unit, Hospital Universitario de Canarias, La Laguna, Spain., Rodríguez-Rodríguez AE; Faculty of Medicine, University of La Laguna, Tenerife, Spain., Díaz Martín L; UCICEC (Unidad Central de Investigación Clínica y Ensayos Clínicos), Research Unit, Hospital Universitario de Canarias, La Laguna, Spain., González Rinne F; Laboratory of Renal Function (LFR), Faculty of Medicine, University of La Laguna, Tenerife, Spain., Marrero Miranda D; Nephrology Unit, Hospital Universitario de Canarias (HUC), La Laguna, Spain., González Rinne A; Nephrology Unit, Hospital Universitario de Canarias (HUC), La Laguna, Spain., Álvarez González A; Nephrology Unit, Hospital Universitario de Canarias (HUC), La Laguna, Spain., Pérez Tamajón L; Nephrology Unit, Hospital Universitario de Canarias (HUC), La Laguna, Spain., Acosta Sørensen C; Nephrology Unit, Hospital Universitario de Canarias (HUC), La Laguna, Spain., Rodríguez Hernández A; Nephrology Unit, Hospital Universitario de Canarias (HUC), La Laguna, Spain., Domínguez-Rodríguez A; Department of Cardiology, Hospital Universitario de Canarias (HUC), La Laguna, Spain.; CIBER of Cardiovascular diseases (CIBERCV), Madrid, Spain.; Faculty of Health Science, Europe university of Canary Island, Tenerife, Spain., García Baute MDC; Department of Cardiology, Hospital Universitario de Canarias (HUC), La Laguna, Spain., Torres Ramírez A; Faculty of Medicine, University of La Laguna, Tenerife, Spain.; Nephrology Unit, Hospital Universitario de Canarias (HUC), La Laguna, Spain.; Instituto de Tecnologías Biomédicas (ITB), Faculty of Medicine, University of La Laguna, Tenerife, Spain., Porrini E; Faculty of Medicine, University of La Laguna, Tenerife, Spain, esteban.l.porrini@gmail.com.; Instituto de Tecnologías Biomédicas (ITB), Faculty of Medicine, University of La Laguna, Tenerife, Spain, esteban.l.porrini@gmail.com.
Jazyk:	angličtina
Zdroj:	Nephron [Nephron] 2021; Vol. 145 (1), pp. 55-62. Date of Electronic Publication: 2020 Dec 02.
DOI:	10.1159/000511320
Abstrakt:	Background: Post-transplant diabetes mellitus (PTDM) is a frequent and severe complication after renal transplantation. In fact, PTDM is a risk factor for both infection and cardiovascular diseases. The prevalence and incidence of PTDM have a bimodal evolution: early (up to 3 months) and late PTDM (beyond 12 months). The majority of late PTDM occurs in subjects with prediabetes after transplantation. So, treating patients with prediabetes, a potentially reversible condition, might help preventing PTDM. In the general population, exercise prevents the evolution from prediabetes to diabetes. However, in renal transplantation, not enough evidence is available in this field. Objectives: We designed an exploratory analysis to evaluate the feasibility of exercise to reverse prediabetes as a first step in the design of a trial to prevent PTDM. Methods: Only patients with prediabetes beyond 12 months after transplantation with capacity to perform exercise will be included. Prediabetes will be diagnosed based on fasting glucose levels and oral glucose tolerance tests (OGTTs). Patients will be treated with a stepped training intervention, starting with aerobic exercise training (brisk walking, swimming, and cycling) 5 times per week and 30 min/day. Aerobic exercise training will be gradually increased to 60 min/day or eventually combined with anaerobic exercise training in case of persistent prediabetes. The reversibility/persistence of prediabetes will be measured with fasting glucose and OGTTs every 3 months. This study will last for 12 months. (© 2020 S. Karger AG, Basel.)
Databáze:	MEDLINE
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