Clinical characteristics and outcomes among Brazilian patients with severe acute respiratory syndrome coronavirus 2 infection: an observational retrospective study.

Autor:	Nascimento IJBD; PharmD. Clinical Pathologist and Medical Research Specialist, University Hospital and School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte (MG), Brazil; Medical Research Specialist, School of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, United States., Pinto LR; PhD. Full Professor, Department of Production Engineering, School of Engineering, Universidade Federal de Minas Gerais, Belo Horizonte (MG), Brazil., Fernandes VA; MSc, PhD. Researcher, University Hospital and School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte (MG), Brazil., Romero IM; MD, PhD. Medical Researcher, Department of Infectious Diseases, Vall d'Hebron Hospital, Barcelona, Spain; Medical Researcher, Instituto Renê Rachou, Fiocruz Minas, Belo Horizonte (MG), Brazil., Oliveira JAQ; PharmB, MSc. Doctoral Student, University Hospital and School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte (MG), Brazil., Marcolino MS; MD, PhD. Full Professor, University Hospital and School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte (MG), Brazil., Leite MF; PharmD, PhD. Full Professor, Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte (MG), Brazil.
Jazyk:	angličtina
Zdroj:	Sao Paulo medical journal = Revista paulista de medicina [Sao Paulo Med J] 2020 Nov-Dec; Vol. 138 (6), pp. 490-497.
DOI:	10.1590/1516-3180.2020.00365.R1.08092020
Abstrakt:	Background: Since February 2020, data on the clinical features of patients infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and their clinical evolution have been gathered and intensively discussed, especially in countries with dramatic dissemination of this disease. Objective: To assess the clinical features of Brazilian patients with SARS-CoV-2 and analyze its local epidemiological features. Design and Setting: Observational retrospective study conducted using data from an official electronic platform for recording confirmed SARS-CoV-2 cases. Methods: We extracted data from patients based in the state of Pernambuco who were registered on the platform of the Center for Strategic Health Surveillance Information, between February 26 and May 25, 2020. Clinical signs/symptoms, case evolution over time, distribution of confirmed, recovered and fatal cases and relationship between age group and gender were assessed. Results: We included 28,854 patients who were positive for SARS-CoV-2 (56.13% females), of median age 44.18 years. SARS-CoV-2 infection was most frequent among adults aged 30-39 years. Among cases that progressed to death, the most frequent age range was 70-79 years. Overall, the mortality rate in the cohort was 8.06%; recovery rate, 30.7%; and hospital admission rate (up to the end of follow-up), 17.3%. The average length of time between symptom onset and death was 10.3 days. The most commonly reported symptoms were coughing (42.39%), fever (38.03%) and dyspnea/respiratory distress with oxygen saturation < 95% (30.98%). Conclusion: Coughing, fever and dyspnea/respiratory distress with oxygen saturation < 95% were the commonest symptoms. The case-fatality rate was 8.06% and the hospitalization rate, 17.3%.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu