CXCL-8-dependent and -independent neutrophil activation in COPD: experiences from a pilot study of the CXCR2 antagonist danirixin.

Autor:	Keir HR; Ninewells Clinical Research Centre, University of Dundee, Dundee, UK., Richardson H; Ninewells Clinical Research Centre, University of Dundee, Dundee, UK., Fillmore C; GSK R&D, Stevenage, UK., Shoemark A; Ninewells Clinical Research Centre, University of Dundee, Dundee, UK., Lazaar AL; GSK R&D, Collegeville, PA, USA., Miller BE; GSK R&D, Collegeville, PA, USA., Tal-Singer R; GSK R&D, Collegeville, PA, USA., Chalmers JD; Ninewells Clinical Research Centre, University of Dundee, Dundee, UK., Mohan D; GSK R&D, Collegeville, PA, USA.
Jazyk:	angličtina
Zdroj:	ERJ open research [ERJ Open Res] 2020 Nov 10; Vol. 6 (4). Date of Electronic Publication: 2020 Nov 10 (Print Publication: 2020).
DOI:	10.1183/23120541.00583-2020
Abstrakt:	The implications of these findings are significant for development of CXCR2 antagonists and other mechanisms targeting neutrophil activation or NETosis, suggesting that IL-8-dependent mechanisms will only work in a subset of COPD patients https://bit.ly/32SeisO. Competing Interests: Conflict of interest: H.R. Keir has nothing to disclose. Conflict of interest: H. Richardson has nothing to disclose. Conflict of interest: C. Fillimore is an employee of and shareholder in GSK. Conflict of interest: A. Shoemark has nothing to disclose. Conflict of interest: A.L. Lazaar is an employee of and shareholder in GSK. Conflict of interest: B.E. Miller is an employee of and shareholder in GSK. Conflict of interest: R. Tal-Singer is a former employee of and current shareholder in GSK, and reports personal fees from Immunomet outside the submitted work. Conflict of interest: J.D. Chalmers reports grants from GSK during the conduct of the study; and grants and personal fees from AstraZeneca and Boehringer Ingelheim, grants from Gilead Sciences, grants and personal fees from Grifols and Insmed, and personal fees from GSK, Chiesi, Napp, Novartis and Zambon, outside the submitted work. Conflict of interest: D. Mohan is an employee of and shareholder in GSK. (Copyright ©ERS 2020.)
Databáze:	MEDLINE
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