Influence of maternal pre-pregnancy nutritional status on offspring anthropometric measurements and body composition in three Brazilian Birth Cohorts.

Autor:	Dias MDS; Postgraduate Program in Epidemiology, Federal University of Pelotas, Marechal Deodoro, 1160 3° floor, Pelotas, Pelotas 96020-220, Brazil., Matijasevich A; Departamento de Medicina Preventiva, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, SP, Brasil., Barros AJ; Postgraduate Program in Epidemiology, Federal University of Pelotas, Marechal Deodoro, 1160 3° floor, Pelotas, Pelotas 96020-220, Brazil., Menezes AMB; Postgraduate Program in Epidemiology, Federal University of Pelotas, Marechal Deodoro, 1160 3° floor, Pelotas, Pelotas 96020-220, Brazil., Schneider BC; Postgraduate Program in Epidemiology, Federal University of Pelotas, Marechal Deodoro, 1160 3° floor, Pelotas, Pelotas 96020-220, Brazil., Hartwig FP; Postgraduate Program in Epidemiology, Federal University of Pelotas, Marechal Deodoro, 1160 3° floor, Pelotas, Pelotas 96020-220, Brazil.; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Barros FC; Postgraduate Program in Epidemiology, Federal University of Pelotas, Marechal Deodoro, 1160 3° floor, Pelotas, Pelotas 96020-220, Brazil., Wehrmeister FC; Postgraduate Program in Epidemiology, Federal University of Pelotas, Marechal Deodoro, 1160 3° floor, Pelotas, Pelotas 96020-220, Brazil., Gonçalves H; Postgraduate Program in Epidemiology, Federal University of Pelotas, Marechal Deodoro, 1160 3° floor, Pelotas, Pelotas 96020-220, Brazil., Santos IS; Postgraduate Program in Epidemiology, Federal University of Pelotas, Marechal Deodoro, 1160 3° floor, Pelotas, Pelotas 96020-220, Brazil.; Postgraduate Program in Pediatrics and Child Health, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil., Assunção MCF; Postgraduate Program in Epidemiology, Federal University of Pelotas, Marechal Deodoro, 1160 3° floor, Pelotas, Pelotas 96020-220, Brazil., Horta BL; Postgraduate Program in Epidemiology, Federal University of Pelotas, Marechal Deodoro, 1160 3° floor, Pelotas, Pelotas 96020-220, Brazil.
Jazyk:	angličtina
Zdroj:	Public health nutrition [Public Health Nutr] 2021 Apr; Vol. 24 (5), pp. 882-894. Date of Electronic Publication: 2020 Dec 02.
DOI:	10.1017/S1368980020004887
Abstrakt:	Objective: We aimed at evaluating the association of maternal pre-pregnancy nutritional status with offspring anthropometry and body composition. We also evaluated whether these associations were modified by gender, diet and physical activity and mediated by birth weight. Design: Birth cohort study. Setting: Waist circumference was measured with an inextensible tape, and fat and lean mass were measured using dual-energy X-ray absorptiometry. Multiple linear regression was used to adjust for possible confounders and allele score of BMI. We carried out mediation analysis using G-formula. Participants: In 1982, 1993 and 2004, all maternity hospitals in Pelotas (South Brazil) were visited daily and all live births whose families lived in the urban area of the city were evaluated. These subjects have been followed up at different ages. Results: Offspring of obese mothers had on average higher BMI, waist circumference and fat mass index than those of normal weight mothers, and these differences were higher among daughters. The magnitudes of the association were similar in the cohorts, except for height, where the association pattern was not clear. In the 1982 cohort, further adjustment for a BMI allele score had no material influence on the magnitude of the associations. Mediation analyses showed that birth weight captured part of this association. Conclusions: Our findings suggest that maternal pre-pregnancy nutritional status is positively associated with offspring BMI and adiposity in offspring. And this association is higher among daughters whose mother was overweight or obese and, birth weight explains part of this association.
Databáze:	MEDLINE
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