| Autor: |
Tavares RL; Experimental Nutrition Laboratory, Department of Nutrition, Federal University of Paraíba, Cidade Universitária, s/n-Castelo Branco III, João Pessoa 58051-085, Brazil., Vasconcelos MHA; Experimental Nutrition Laboratory, Department of Nutrition, Federal University of Paraíba, Cidade Universitária, s/n-Castelo Branco III, João Pessoa 58051-085, Brazil., Dutra MLDV; Experimental Nutrition Laboratory, Department of Nutrition, Federal University of Paraíba, Cidade Universitária, s/n-Castelo Branco III, João Pessoa 58051-085, Brazil., D'Oliveira AB; Experimental Nutrition Laboratory, Department of Nutrition, Federal University of Paraíba, Cidade Universitária, s/n-Castelo Branco III, João Pessoa 58051-085, Brazil., Lima MDS; Department of Food Technology, Federal Institute of Sertão Pernambucano, Rod. BR 407 km 08, s/n-Jardim São Paulo, Petrolina 56314-522, Brazil., Salvadori MGDSS; Department of Psychology, Federal University of Paraíba, Cidade Universitária, s/n-Castelo Branco III, João Pessoa 58051-085, Brazil., Pereira RA; Pathology Laboratory, Department of Pathology, Federal University of Minas Gerais, Av. Pres. Antônio Carlos, n.6627-Pampulha, Belo Horizonte 31270-901, Brazil., Alves AF; Department of Physiology and Pathology, Federal University of Paraíba, Cidade Universitária, s/n-Castelo Branco III, João Pessoa 58051-085, Brazil., Nascimento YMD; Pharmaceutical Technology Laboratory, Department of Pharmaceutical Sciences, Federal University of Paraíba, Cidade Universitária, s/n-Castelo Branco III, João Pessoa 58051-085, Brazil., Tavares JF; Pharmaceutical Technology Laboratory, Department of Pharmaceutical Sciences, Federal University of Paraíba, Cidade Universitária, s/n-Castelo Branco III, João Pessoa 58051-085, Brazil., Guzman-Quevedo O; Laboratory Neuronutrition and Metabolic Disorders, Higher Technological Institute of Tacámbaro, Av. Tecnológico 201, Tecario, Tacámbaro 61651, Mexico., Aquino JS; Experimental Nutrition Laboratory, Department of Nutrition, Federal University of Paraíba, Cidade Universitária, s/n-Castelo Branco III, João Pessoa 58051-085, Brazil. |
| Abstrakt: |
This study evaluated the effect of Mucuna pruriens (MP) administration on neuroinflammation and behavioral and murinometric parameters in obese rats. Proximate composition, oligosaccharide and phenolic compound profile of MP were determined. Wistar adult male rats were randomized into healthy (HG) and obese group (OG). The HG consumed a control chow diet while OG consumed a cafeteria diet for eight weeks. Then, they were subdivided into: Healthy (HG); Healthy with MP administration (HGMP); Obese (OG); Obese with MP administration (OGMP), with the consumption of the respective diets remaining for another eight weeks, in addition to gavage with MP extract to supplemented groups (750 mg/kg weight). MP presented a composition rich in proteins and phenolic compounds, especially catechin, in addition to 1-kestose and levodopa. Supplementation reduced food intake, body weight, and thoracic and abdominal circumferences in obese rats. MP showed anxiolytic and antidepressant effects and reduced morphological damage and expression of interleukin 6 in the hippocampus of obese rats. MP treatment showed satietogenic, slimming, anxiolytic and antidepressant effects, besides to minimizing hippocampal neuroinflammation in obese rats. Our results demonstrated the potential anti-obesity of MP which are probably related to the high content of bioactive compounds present in this plant extract. |
