A Distinct EEG Marker of Celiac Disease-Related Cortical Myoclonus.

Autor: Swinkin E; Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital and Division of Neurology, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, Canada., Lizárraga KJ; Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital and Division of Neurology, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, Canada.; Motor Physiology and Neuromodulation Program, Division of Movement Disorders and Center for Health and Technology (CHeT), Department of Neurology, University of Rochester, Rochester, New York, USA., Algarni M; Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital and Division of Neurology, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, Canada.; Division of Neurology, East Jeddah Hospital, Jeddah, Saudi Arabia., Garcia Dominguez L; Mitchell Goldhar MEG Unit, Clinical Neurophysiology Laboratory, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada., Baarbé JK; Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.; Institute of Medical Science, School of Graduate Studies, University of Toronto, Toronto, Ontario, Canada., Saravanamuttu J; Krembil Research Institute, University Health Network, Toronto, Ontario, Canada., Chen R; Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital and Division of Neurology, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, Canada.; Krembil Research Institute, University Health Network, Toronto, Ontario, Canada., Slow E; Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital and Division of Neurology, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, Canada., Lang AE; Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital and Division of Neurology, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, Canada.; Krembil Research Institute, University Health Network, Toronto, Ontario, Canada., Wennberg RA; Mitchell Goldhar MEG Unit, Clinical Neurophysiology Laboratory, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
Jazyk: angličtina
Zdroj: Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2021 Apr; Vol. 36 (4), pp. 999-1005. Date of Electronic Publication: 2020 Nov 30.
DOI: 10.1002/mds.28407
Abstrakt: Background: Celiac disease is associated with motor cortex hyperexcitability and neurological manifestations including cortical myoclonus. Electroencephalography abnormalities have been described, but no distinct pattern has been reported.
Methods: We describe the neurophysiological characteristics of 3 patients with celiac-associated cortical myoclonus using electroencephalography, magnetoencephalography, and transcranial magnetic stimulation.
Results: Electroencephalography in all cases demonstrated lateralized low-amplitude, electropositive beta-frequency polyspike activity over the central head region, corresponding to motor cortex contralateral to the myoclonic limb. Jerk-locked back-averaging demonstrated a preceding cortical potential; magnetoencephalography source localization revealed a cortical generator in the posterior wall of the precentral gyrus for the back-averaged potential and oscillatory abnormality. In 1 patient, cerebellar inhibition of the motor cortex was physiologically normal.
Conclusions: Central head oscillatory, low-amplitude, electropositive electroencephalography polyspike activity may be a distinct marker of celiac-related cortical myoclonus and is consistent with celiac-related motor cortex hyperexcitability, which may not necessarily result from cerebellar disinhibition. © 2020 International Parkinson and Movement Disorder Society.
(© 2020 International Parkinson and Movement Disorder Society.)
Databáze: MEDLINE
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