Behavioral and EEGraphic Characterization of the Anticonvulsant Effects of the Predator Odor (TMT) in the Amygdala Rapid Kindling, a Model of Temporal Lobe Epilepsy.

Autor:	Delfino-Pereira P; Department of Neuroscience and Behavioral Sciences, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, Brazil.; Department of Physiology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil., Bertti-Dutra P; Department of Neuroscience and Behavioral Sciences, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, Brazil.; Department of Physiology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil., Del Vecchio F; Department of Physiology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil., de Oliveira JAC; Department of Physiology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil., Medeiros DC; Department of Physiology and Biophysics, Institute of Biological Science Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, Brazil.; Electrical Engineering Graduate Program, Federal University of Minas Gerais, Belo Horizonte, Brazil., Cestari DM; Department of Computer Science, Institute of Mathematics and Computer Sciences, University of São Paulo, São Carlos, Brazil., Santos VR; Department of Physiology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.; Department of Morphology, Institute of Biological Science Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, Brazil., Moraes MFD; Department of Physiology and Biophysics, Institute of Biological Science Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, Brazil., Rosa JLG; Department of Computer Science, Institute of Mathematics and Computer Sciences, University of São Paulo, São Carlos, Brazil., Mendes EMAM; Electrical Engineering Graduate Program, Federal University of Minas Gerais, Belo Horizonte, Brazil., Garcia-Cairasco N; Department of Neuroscience and Behavioral Sciences, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, Brazil.; Department of Physiology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in neurology [Front Neurol] 2020 Nov 05; Vol. 11, pp. 586724. Date of Electronic Publication: 2020 Nov 05 (Print Publication: 2020).
DOI:	10.3389/fneur.2020.586724
Abstrakt:	Background: Clinical and experimental evidence indicates that olfactory stimulation modulates limbic seizures, either blocking or inducing ictal activity. Objective: We aim to evaluate the behavioral and electroencephalographic (EEGraphic) effects of dihydro-2,4,5-trimethylthiazoline (TMT) olfactory exposure on limbic seizures induced by amygdala rapid kindling (ARK). Materials and Methods: Wistar male rats (280-300 g) underwent stereotaxic surgery for electrode implantation in piriform cortex (PC), hippocampal formation (HIP), and amygdaloid complex (AMYG). Part of the animals was exposed to a saturated chamber with water or TMT, while others had ARK and olfactory exposure prior to the 21st stimulus. Behavioral responses were measured by traditional seizure severity scales (Racine and Pinel and Rovner) and/or by sequential analysis/neuroethology. The electrographic activity of epileptogenic limbic networks was quantified by the occurrence of the first and second EEG afterdischarges, comparing the 1st and 21st stimulus. The spectral analysis [Fast Fourier Transform (FFT)] of the first afterdischarge was performed at the 21st stimulus. Results: TMT olfactory exposure reduced the seizure severity in kindled rats, altering the displayed behavioral sequence. Moreover, TMT decreased the occurrence of first and second afterdischarges, at the 21st stimulus, and altered the spectral features. Conclusions: Both behavioral and EEGraphic evaluations indicated that TMT, a potent molecule with strong biological relevance, in fact, "predator odor," suppressed the epileptiform activity in limbic networks. (Copyright © 2020 Delfino-Pereira, Bertti-Dutra, Del Vecchio, de Oliveira, Medeiros, Cestari, Santos, Moraes, Rosa, Mendes and Garcia-Cairasco.)
Databáze:	MEDLINE
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