| Autor: |
Tomoda Y; Diabetes Center, Toyonaka Municipal Hospital, Japan., Okauchi Y; Diabetes Center, Toyonaka Municipal Hospital, Japan., Deguchi A; Diabetes Center, Toyonaka Municipal Hospital, Japan., Takenoshita Y; Diabetes Center, Toyonaka Municipal Hospital, Japan., Iwahashi H; Diabetes Center, Toyonaka Municipal Hospital, Japan., Mineo I; Diabetes Center, Toyonaka Municipal Hospital, Japan. |
| Jazyk: |
angličtina |
| Zdroj: |
Internal medicine (Tokyo, Japan) [Intern Med] 2021 May 01; Vol. 60 (9), pp. 1423-1426. Date of Electronic Publication: 2020 Nov 30. |
| DOI: |
10.2169/internalmedicine.5267-20 |
| Abstrakt: |
We report the case of a 52-year-old woman with Prader-Willi syndrome (PWS) and diabetes. Her diabetes was managed with sulfonylurea followed by premixed insulin; however, her glycemic control gradually worsened and became unstable. Her urine and blood C-peptide levels were undetectable. She tested positive for anti-GAD antibodies, and had a high-risk genotype - DRB1*09:01-DQB1*03:03 - for slowly progressive insulin-dependent diabetes mellitus (SPIDDM) in the HLA-DR/DQ region, confirming the diagnosis of SPIDDM. Dysglycemia in PWS is thought to be attributable to hyperphagia and obesity. However, the possibility of SPIDDM might be considered if the insulin secretory capacity is almost lost in patients with PWS. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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