Hepatotoxicity of the anionic surfactant linear alkylbenzene sulphonate (LAS) in bullfrog tadpoles.

Autor: Franco-Belussi L; Laboratório de Fisiologia da Conservação (LAFISC), Universidade Federal de São Carlos (UFSCar), Sorocaba, São Paulo, Brazil; Departamento de Biologia, Universidade Estadual Paulista (UNESP), São José do Rio Preto, São Paulo, Brazil; Laboratório de Patologia Experimental (LAPEx), Instituto de Biociências (INBIO), Universidade Federal de Mato Grosso do Sul, UFMS, Campo Grande, Mato Grosso do Sul, Brazil. Electronic address: lilian.belussi@gmail.com., Jones-Costa M; Laboratório de Fisiologia da Conservação (LAFISC), Universidade Federal de São Carlos (UFSCar), Sorocaba, São Paulo, Brazil., Salla RF; Laboratório de Fisiologia da Conservação (LAFISC), Universidade Federal de São Carlos (UFSCar), Sorocaba, São Paulo, Brazil., Souza BFS; Laboratório de Fisiologia da Conservação (LAFISC), Universidade Federal de São Carlos (UFSCar), Sorocaba, São Paulo, Brazil., Pinto-Vidal FA; Laboratório de Fisiologia da Conservação (LAFISC), Universidade Federal de São Carlos (UFSCar), Sorocaba, São Paulo, Brazil; RECETOX, Faculty of Science, Masaryk University, Kamenice 753/5, Pavilion A29, 625 00 Brno, Czech Republic., Oliveira CR; Laboratório de Fisiologia da Conservação (LAFISC), Universidade Federal de São Carlos (UFSCar), Sorocaba, São Paulo, Brazil., Silva-Zacarin ECM; Laboratório de Ecotoxicologia e Biomarcadores Em Animais (LEBA), Universidade Federal de São Carlos, Sorocaba, São Paulo, Brazil., Abdalla FC; Laboratório de Biologia Estrutural e Funcional, Universidade Federal de São Carlos, Sorocaba, São Paulo, Brazil., Duarte ICS; Laboratório de Microbiologia Ambiental (LAMA), Universidade Federal de São Carlos, Sorocaba, São Paulo, Brazil., De Oliveira C; Departamento de Biologia, Universidade Estadual Paulista (UNESP), São José do Rio Preto, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Chemosphere [Chemosphere] 2021 Mar; Vol. 266, pp. 129014. Date of Electronic Publication: 2020 Nov 18.
DOI: 10.1016/j.chemosphere.2020.129014
Abstrakt: The liver of anurans play an important role in metabolism, including detoxification, the biotransformation of molecules, and the storage of metabolites. Surfactants are part of domestic and industrial effluents. The effects of linear alkylbenzene sulfonate (LAS) on anuran liver remain unknown, however, some studies have evaluated the effects of LAS on the skin, gills, heart, testes, and liver of fishes. Here, we tested the hypothesis that LAS is hepatotoxic, promoting morphometric alterations in hepatocytes along with inflammation in the tissue, altering hepatic catabolism. We evaluated the effects of a LAS concentration that is considered environmentally safe in Brazilian inland waters on the liver of Lithobates catesbeianus tadpoles, including studies on morphology, morphometry, immunology, and metabolism. LAS exposure promoted enlargement of liver sinusoids and vacuolization of hepatocytes. Exposure to LAS also increased the area of mast cells and melanomacrophages (MMs). Additionally, LAS exposure increased hemosiderin inside MMs, suggesting alterations in the catabolism and storage of iron. Hepatocyte size increased after exposure to LAS, suggesting cytotoxic effects. Integrative analyses (i.e., morphometric, metabolic, and immunological) demonstrated hepatotoxic effects of LAS. These types of studies are key to understanding the negative effects of these substances on tadpole health, as these liver alterations impair anuran homeostasis.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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