Fish oil supplementation enhances colon recovery after experimental colitis.

Autor: Soares IP; Department of Physiology, Federal University of Parana, Curitiba, Brazil. Electronic address: pedrosoigorr@gmail.com., Oliveira BAC; Department of Molecular Biology, Federal University of Parana, Curitiba, Brazil., Baal SCS; Department of Physiology, Federal University of Parana, Curitiba, Brazil., Donatti L; Department of Molecular Biology, Federal University of Parana, Curitiba, Brazil., Ingberman M; Imunova Análises Biológicas, Curitiba, Brazil., Beirão BCB; Department of Pathology, Federal University of Parana, Curitiba, Brazil., Appel MH; Department of Genetics, Structural and Molecular Biology, State University of Ponta Grossa, Ponta Grossa, Brazil., Fernandes LC; Department of Physiology, Federal University of Parana, Curitiba, Brazil.
Jazyk: angličtina
Zdroj: Prostaglandins, leukotrienes, and essential fatty acids [Prostaglandins Leukot Essent Fatty Acids] 2020 Dec; Vol. 163, pp. 102212. Date of Electronic Publication: 2020 Nov 18.
DOI: 10.1016/j.plefa.2020.102212
Abstrakt: Introduction: Fish oil (FO) has an anti-inflammatory and pro-resolution activity and it has been used to restore physiological disturbances on inflammatory conditions. Here, we investigate whether FO supplementation could, acutely, prevent or restore inflammatory damages on experimental colitis.
Methods: Wistar rats orally received 2 g.kg -1 .day -1 of FO for 30 days before induction of experimental colitis. Specimens were collected on the 2nd and 7th days after colitis-induction and intestinal mucus, inflammatory activity and colon integrity were determined.
Results: Experimental colitis did cause colon disruption and FO, acutely, did not prevent the loss of intestinal and fecal mucus, neither the increase of inflammatory activity and intestinal permeability. On the 7th day of colitis, FO soften the perturbations of experimental colitis, increasing histological and fecal mucus and, also decreased inflammatory activity, but this was not accompanied by intestinal permeability.
Conclusion: FO did not protect, acutely, intestinal damages from experimental colitis, but at long run promotes higher intestinal recovery.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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