Prenatal developmental toxicity studies on fumes from bitumen in the rat.

Autor: Boogaard PJ; Shell Health, Shell International Bv, PO Box 162, The Hague, 2501 AN, The Netherlands; Toxicology Group in CONCAWE, Belgium. Electronic address: peter.boogaard@shell.com., Buschmann J; General and Reproductive Toxicology Consultancy, Haegewiesen 93, Hannover, 30657, Germany; Fraunhofer Institute for Toxicology and Experimental Medicine, Nikolai-Fuchs-Straße 1, Hannover, 30625, Germany. Electronic address: jbuschm333@aol.com., Fuhst R; Fraunhofer Institute for Toxicology and Experimental Medicine, Nikolai-Fuchs-Straße 1, Hannover, 30625, Germany., Blümlein K; Fraunhofer Institute for Toxicology and Experimental Medicine, Nikolai-Fuchs-Straße 1, Hannover, 30625, Germany., Schwarz K; Fraunhofer Institute for Toxicology and Experimental Medicine, Nikolai-Fuchs-Straße 1, Hannover, 30625, Germany., Schaudien D; Fraunhofer Institute for Toxicology and Experimental Medicine, Nikolai-Fuchs-Straße 1, Hannover, 30625, Germany., Koch W; Fraunhofer Institute for Toxicology and Experimental Medicine, Nikolai-Fuchs-Straße 1, Hannover, 30625, Germany. Electronic address: wolfgang.koch@item.fraunhofer.de., McAlinden C; toXcel International, PO Box 93, Ledbury, Herefordshire, HR8 9JE, United Kingdom. Electronic address: christine.mcalinden@toxcel.co.uk., Deferme L; ExxonMobil Petroleum and Chemical Bv, Hermeslaan 2, Machelen, 1831, Belgium; Toxicology Group in CONCAWE, Belgium. Electronic address: lize.deferme@exxonmobil.com., Vaissiere M; Total, 24 Cours Michelet, Puteaux, 92800, France; Toxicology Group in CONCAWE, Belgium. Electronic address: mathieu.vaissiere@total.com., Ketelslegers HB; CONCAWE, Vorstlaan 165, Brussels, B-1160, Belgium. Electronic address: hans.ketelslegers@concawe.eu., Steneholm A; Nynas AB, P.O. Box 10 700, Stockholm, SE-121 29, Sweden; Toxicology Group in CONCAWE, Belgium. Electronic address: anna.steneholm@nynas.com.
Jazyk: angličtina
Zdroj: Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2021 Jan; Vol. 99, pp. 15-26. Date of Electronic Publication: 2020 Nov 26.
DOI: 10.1016/j.reprotox.2020.11.009
Abstrakt: The prenatal developmental toxicity of bitumen fume was tested by nose-only inhalation in the rat. The fumes for exposure were collected from the headspace of a storage tank filled with a bitumen corresponding in composition to an anticipated worst-case occupational exposure. The composition of these fumes was compared to actual paving site fumes to ensure its representativeness for workplace exposures. In a dose-range-finding study male and female rats were exposed to 0, 103, 480 or 1043 mg/m 3 of fume (as total organic mass), for 6 h/day during 20 days post conception (p.c.). Dose-related effects on body weight and lungs were observed in the mid- and high-dose groups. In the main study, dams were exposed to 0, 52, 151 and 482 mg/m 3 of fume, for 6 h/day during 19 days p.c. The maternal NOAEL was 52 mg/m³. In the high-dose group treatment-related effects on body weight (gain), food consumption, lung weights, and histopathological changes in lungs and larynx were observed. In the mid-dose group only histopathological changes in the larynx and lungs were found. The NOAEL for prenatal developmental toxicity was 151 mg/m³ based on reduced fetal weight in the high-dose group (482 mg/m³). However, these changes are most likely a consequence of the maternal toxicity, in particular the reduction of maternal body weight gain by 26 % as compared to control. Nose-only exposure to bitumen fumes in concentrations up to 482 mg/m³ from days 1-19 p.c. did not induce any significant fetal anomalies.
Competing Interests: Declaration of Competing Interest Peter J. Boogaard, Lize Deferme, Mathieu Vaissiere and Anna Steneholm are employed by a company that produces bitumen. However, they undertook this work as members of the Toxicology Group of Concawe, the scientific division of the European Petroleum Refiners Association, and were completely free in the conduct as well as the expression of their scientific opinion in this paper. The other authors have no conflict of interest.
(Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE