Anxiety-like behavior and neuroendocrine changes in offspring resulting from gestational post-traumatic stress disorder.

Autor: Chagas LA; Instituto de Ciências Biomédicas, Universidade Federal de Alfenas, Alfenas, Brazil., Batista TH; Instituto de Ciências Biomédicas, Universidade Federal de Alfenas, Alfenas, Brazil., Ribeiro ACAF; Instituto de Ciências Biomédicas, Universidade Federal de Alfenas, Alfenas, Brazil., Ferrari MS; Instituto de Ciências Biomédicas, Universidade Federal de Alfenas, Alfenas, Brazil., Vieira JS; Instituto de Ciências Biomédicas, Universidade Federal de Alfenas, Alfenas, Brazil., Rojas VCT; Instituto de Ciências Biomédicas, Universidade Federal de Alfenas, Alfenas, Brazil., Kalil-Cutti B; Instituto de Ciências Biomédicas, Universidade Federal de Alfenas, Alfenas, Brazil., Elias LLK; Departmento de Fisiologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brazil., Giusti-Paiva A; Instituto de Ciências Biomédicas, Universidade Federal de Alfenas, Alfenas, Brazil., Vilela FC; Instituto de Ciências Biomédicas, Universidade Federal de Alfenas, Alfenas, Brazil. Electronic address: facvilela@gmail.com.
Jazyk: angličtina
Zdroj: Behavioural brain research [Behav Brain Res] 2021 Feb 05; Vol. 399, pp. 113026. Date of Electronic Publication: 2020 Nov 25.
DOI: 10.1016/j.bbr.2020.113026
Abstrakt: Exposure to stressful environmental events during the perinatal period can increase vulnerability to psychopathologies that cause neuroendocrine changes associated with deficits in emotional behavior that can appear early in life. Post-traumatic stress disorder (PTSD) is a frequent, chronic, and disabling disorder that negatively impacts the emotional, social, and cognitive behaviors of affected individuals. Thus, we induced PTSD in pregnant rats by applying inescapable footshocks and then investigated the behavioral parameters similar to anxiety in offspring at prepubertal age, in addition to the plasma levels of maternal and offspring corticosterone and expression of glucocorticoid receptors (GR) in the offspring's hippocampus. With the dams, maternal behavior, open field, and object recognition tests were performed. With the male and female offspring, we performed the following: quantification of ultrasonic vocalizations, elevated plus-maze test, evaluation of exploratory activity in the open field, and hole board test, as well as plasma corticosterone measurements and Western blotting for GR. Our results showed that gestational PTSD affected maternal behavior, led to anxiety-like symptoms, increased corticosterone levels, and increased GR expression in the offspring's hippocampus. Therefore, our data can contribute to the understanding of the onset of early (childhood and juvenile/pre-pubertal phases) anxiety owing to exposure to a traumatic event during the gestation period.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: