The Buspirone-dependent Abdominal Pain Transmission Within the Nucleus Tractus Solitarius in the Rat.

Autor: Panteleev SS; Laboratory of Cortico-Visceral Physiology, Pavlov Institute of Physiology of the Russian Academy of Sciences, 6 Nab. Makarova, Saint-Petersburg 199034, Russia. Electronic address: panteleev0@gmail.com., Sivachenko IB; Laboratory of Cortico-Visceral Physiology, Pavlov Institute of Physiology of the Russian Academy of Sciences, 6 Nab. Makarova, Saint-Petersburg 199034, Russia. Electronic address: AVANS_d@mail.ru., Lyubashina OA; Laboratory of Cortico-Visceral Physiology, Pavlov Institute of Physiology of the Russian Academy of Sciences, 6 Nab. Makarova, Saint-Petersburg 199034, Russia; Department of Neuropharmacology, Valdman Institute of Pharmacology, First Saint-Petersburg Pavlov State Medical University, 6/8 Lev Tolstoy Street, Saint-Petersburg 197022, Russia. Electronic address: lyubashinaoa@infran.ru.
Jazyk: angličtina
Zdroj: Neuroscience [Neuroscience] 2021 Jan 01; Vol. 452, pp. 326-334. Date of Electronic Publication: 2020 Nov 26.
DOI: 10.1016/j.neuroscience.2020.11.032
Abstrakt: Buspirone, a partial agonist of the 5-HT 1a R, due to potential antinociceptive properties can be useful for abdominal pain treatment in IBS patients. Pain-related effects of buspirone can be mediated by the 5-HT 1a Rs, located within the nucleus tractus solitarius. The 5-HT 1a R involvement in pain transmission within the NTS is unclear. The objective of our study was to evaluate the involvement of the 5-HT 1a R in abdominal pain transmission within the NTS. Using a model of abdominal pain on urethane-anesthetized rats, two types of NTS pain-related neurons responding to the noxious colorectal distension (CRD) with excitatory and inhibitory sustained patterns of evoked activity were revealed. Buspirone (1.0-4.0 mg kg -1 , iv) has complex time- and dose-depended action on the CRD-induced NTS neuron responses. Buspirone inhibits the responses of the excitatory neurons and inverts the responses of the inhibitory pain-related neurons but at a dose of 4.0 buspirone, the effect on NTS pain-related neurons attenuates. The inhibitory effect of buspirone on the CRD-evoked responses of the excitatory NTS neurons is completely blocked by an intra-cerebroventricular administration of buspirone agonist WAY100,635. The inhibitory responses do not change by this agonist. The inhibitory action of buspirone is mediated by supraspinal 5-HT 1a receptors however, its excitatory effect on inhibitory neurons does not dependents on these receptors. We proposed that the NTS pain-related neurons could be involved in anti- or pronociceptive effects of buspirone on abdominal pain.
(Copyright © 2020 IBRO. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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