Malignant transformation of oral leukoplakia: a multicentric retrospective study in Brazilian population.
| Autor: | Cerqueira JM; Department of Surgery and Oral Pathology João de Barros Barreto University Hospital Mundurucus Street, nº 4487 Zip Code 66073-000, Belém, Pará, Brazil harp@ufpa.br., Pontes FS, Santos-Silva AR, Almeida OP, Costa RF, Fonseca FP, Gomez RS, Neto NC, Miyahara LA, Rodrigues-Fernandes CI, Neto ED, Araújo AL |
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| Jazyk: | angličtina |
| Zdroj: | Medicina oral, patologia oral y cirugia bucal [Med Oral Patol Oral Cir Bucal] 2021 May 01; Vol. 26 (3), pp. e292-e298. Date of Electronic Publication: 2021 May 01. |
| DOI: | 10.4317/medoral.24175 |
| Abstrakt: | Background: Among the oral potentially malignant disorders, leukoplakia stands out as the most prevalent. The purpose of this study was to analyse the clinical-pathological features of oral leukoplakia in groups of patients from three major pathology centers in two different regions of Brazil, in order to determine which factors would be associated to the clinical risk of malignant transformation. Material and Methods: A total of 148 patients was analyzed, and data regarding gender, age, site, classification of the clinical subtype, harmful habits such as use of tobacco and alcohol, time of evolution and presence of dysplasia were collected. The association between risk factors and malignant transformation was investigated using the chi-square test and Fischer's exact test for correlation of variables. A significance level of 5% (p≤0.05) was used. Results: The mean age of the patients was 60 years, and 56% were female. Most of the lesions (34,5%) were located in the lateral and ventral regions of the tongue. Of the 148 patients, ninety had clinical follow-up. Malignant transformation occurred in 13 patients (8.8%), with an average of 44 months of follow up. Conclusions: Non-smoker, nonhomogeneous clinical presentation, location at the tongue, and the presence of high degree of dysplasia were statistically relevant factors associated with a higher risk of transformation transformation. |
| Databáze: | MEDLINE |
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