Multitherapy magnetic theranostic: Synthesis, characterization and in vitro evaluation of their performance.

Autor: Montiel Schneider MG; INQUISUR, Departamento de Química, Universidad Nacional del Sur (UNS)-CONICET, Av. Alem 1253, 8000 Bahía Blanca, Buenos Aires, Argentina. Electronic address: gabriela.montiel@uns.edu.ar., Favatela MF; INQUISUR, Departamento de Química, Universidad Nacional del Sur (UNS)-CONICET, Av. Alem 1253, 8000 Bahía Blanca, Buenos Aires, Argentina., Muñoz Medina GA; Instituto de Física La Plata IFLP-CONICET, Departamento de Física, Universidad Nacional de La Plata, La Plata, Buenos Aires, Argentina., Fernandez van Raap MB; Instituto de Física La Plata IFLP-CONICET, Departamento de Física, Universidad Nacional de La Plata, La Plata, Buenos Aires, Argentina., Lassalle VL; INQUISUR, Departamento de Química, Universidad Nacional del Sur (UNS)-CONICET, Av. Alem 1253, 8000 Bahía Blanca, Buenos Aires, Argentina.
Jazyk: angličtina
Zdroj: Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2021 Feb; Vol. 198, pp. 111460. Date of Electronic Publication: 2020 Nov 12.
DOI: 10.1016/j.colsurfb.2020.111460
Abstrakt: It is well known that iron oxide magnetic nanoparticles (IONPs) have many potential utilities in biomedicine due to their unique physicochemical properties. With the aim to obtain multifunctional nanoparticles with potential uses for therapy and diagnosis (nanotheranostics), IONPs were synthesized by hydrothermal synthesis assisted by mannose. Two synthetic pathways were evaluated in order to obtain IONPs with suitable properties for biomedical applications. The formulation Mag@Man/H1 presented the best characteristics in terms of size and stability. Mag@Man/H1 was evaluated as: a) drug carrier, b) antioxidant activity, c) magnetic hyperthermia, d) contrast agent for MRI. To evaluate the point a), morin, a natural flavonoid with several pharmaceutical activities, was loaded on the nanoparticles. A high percentage of drug loading was achieved. In point b) it was determined that the carrier itself possess a high activity which increased in morin loaded nanoparticles. Point c) magnetocalorimetric evaluation were carried out at several field conditions. A specific absorption rate value of 121.4 W/gFe was achieved at 52.4 kA/m and 260 kHz and 8.8 W/gFe at 4 kA/m and 100 kHz. Regarding contrast capacity (point d), the r1 value found was close to some contrast agent based on manganese. Although the measured r2 value was quite smaller than other iron oxides, the achieved effect was strong enough to produce negative contrast. From these studies, it was concluded that Mag@Man/H1 could act as a multifunctional nanoplatform for oncological diseases treatments.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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