The first parent-child diagnosis of a multifocal squamous odontogenic tumor: A case report.

Autor: Croonenborghs TM; Dept. of Oral and Maxillofacial Surgery, University Hospitals Leuven, Leuven, Belgium; OMFS-IMPATH Research Group, Dept. Imaging & Pathology, Faculty of Medicine, Catholic University Leuven, Leuven, Belgium. Electronic address: tomas-marijn.croonenborghs@uzleuven.be., Fransen J; Dept. of Oral and Maxillofacial Surgery, University Hospitals Leuven, Leuven, Belgium; Dept. of Oral and Maxillofacial Surgery, OLV Hospital Aalst, Aalst, Belgium., Hauben E; Dept. Of Translational Cell & Tissue Research, University Hospitals Leuven, Leuven, Belgium; Dept. of Pathology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium., Peeters H; Dept. of Human Genetics, University Hospitals Leuven, Leuven, Belgium., Politis C; Dept. of Oral and Maxillofacial Surgery, University Hospitals Leuven, Leuven, Belgium; OMFS-IMPATH Research Group, Dept. Imaging & Pathology, Faculty of Medicine, Catholic University Leuven, Leuven, Belgium.
Jazyk: angličtina
Zdroj: Journal of stomatology, oral and maxillofacial surgery [J Stomatol Oral Maxillofac Surg] 2021 Dec; Vol. 122 (6), pp. 612-617. Date of Electronic Publication: 2020 Nov 24.
DOI: 10.1016/j.jormas.2020.11.004
Abstrakt: Squamous odontogenic tumors (SOT) are rare, benign, odontogenic neoplasms of the jaws. The sporadically reported cases with multifocal SOTs seem to have a marked predilection for younger African American patients. In this case report a 14-year-old Caucasian male presented with swelling of the vestibular alveolar process, slight tooth divergence, and mobility. A multifocal squamous odontogenic tumor was diagnosed and subsequently treated twice with surgical enucleation. Two and a half years earlier his mother was diagnosed and treated for a similar multifocal SOT. Next-Generation-Sequencing targeted resequencing mutational analysis of the maternal surgical specimens was performed. No potential causal mutation could be identified. Postoperative follow-up of the patient showed no recurrence of the SOT after 2 years. This case report substantiates the possibility of a familial relationship in (multifocal) SOT, possibly changing current ideas concerning the etiology and treatment of these neoplasms.
(Copyright © 2020 Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
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