| Autor: |
Alessenko AV; Institute of Biochemical Physic of the Russian Academy of Sciences, Moscow, Russia., Gutner UA; Institute of Biochemical Physic of the Russian Academy of Sciences, Moscow, Russia., Nebogatikov VO; Institute of Physiologically Active Compounds of the Russian Academy of Sciences, Moscow Region, Russia., Shupik MA; Institute of Biochemical Physic of the Russian Academy of Sciences, Moscow, Russia., Ustyugov AA; Institute of Physiologically Active Compounds of the Russian Academy of Sciences, Moscow Region, Russia. |
| Jazyk: |
ruština |
| Zdroj: |
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [Zh Nevrol Psikhiatr Im S S Korsakova] 2020; Vol. 120 (10), pp. 108-117. |
| DOI: |
10.17116/jnevro2020120101108 |
| Abstrakt: |
Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease characterized by selective degeneration of motor neurons of the motor cortex, brain stem and brain stem. Mutations in genes coding for SOD1, C9ORF72, TDP-43, FUS and others are associated with ALS and result in abnormal processing and transport of RNA as well as changes in the dynamics of cytoskeleton. In addition, a sharp change in the metabolism of various lipid classes, including phospholipids, fatty acids, sphingolipids, etc., was detected. This review describes changes in lipid content and activity of enzymes involved in their metabolism in ALS animal models as well as in patients. Changes in the metabolism of fatty acids, phospholipids, cholesterol and its derivatives are reviewed in detail. The prospects of searching for new drugs among modulators of lipid metabolism enzymes are discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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