Myopericytoma arising from myopericytosis-a hitherto unrecognized entity within the lung.

Autor: Gruber-Moesenbacher U; Institute of Pathology, Helios Clinics, Gauting, Germany., Morresi-Hauff A; Institute of Pathology, Helios Clinics, Gauting, Germany., Behr K; Institute of Pathology, Mittelthueringen, Bad Berka, Germany., Popper H; Institute of Pathology, Medical University of Graz, Neue Stiftingtalstrasse 6, 8036, Graz, Austria. helmut.popper@medunigraz.at.
Jazyk: angličtina
Zdroj: Virchows Archiv : an international journal of pathology [Virchows Arch] 2021 May; Vol. 478 (5), pp. 841-849. Date of Electronic Publication: 2020 Nov 26.
DOI: 10.1007/s00428-020-02972-9
Abstrakt: Two cases of myopericytosis combined with pericytoma originating within the lung are reported. These are rare pulmonary tumors. The differential diagnosis for hemangiopericytoma and pericytic tumors with glomus elements is discussed. Both myopericytic lesions mimic other lesions, which are more commonly seen in the lung. Based on the expression of vascular growth factor receptors 2 and 3, an antiangiogenic therapy was suggested for the patient with the myopericytoma. A treatment with an angiogenesis inhibitor resulted in a regression of the tumor, but not the precursor lesion. Probably a more specific therapy using tyrosine kinase inhibitors for VEGFR2/3 might better control these myopericytic proliferations.
Databáze: MEDLINE
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