| Autor: |
Wobbe B; Division of Cardiology, 1st Department of Medicine, University of Pécs Medical School, Pécs, Hungary., Wagner J; Division of Cardiology, 1st Department of Medicine, University of Pécs Medical School, Pécs, Hungary., Szabó DK; Division of Cardiology, 1st Department of Medicine, University of Pécs Medical School, Pécs, Hungary., Rostás I; Institute for Translational Medicine, University of Pécs Medical School, Pécs, Hungary., Farkas N; Institute for Translational Medicine, University of Pécs Medical School, Pécs, Hungary., Garami A; Institute for Translational Medicine, University of Pécs Medical School, Pécs, Hungary., Balaskó M; Institute for Translational Medicine, University of Pécs Medical School, Pécs, Hungary., Hartmann P; Institute of Surgical Research, University of Szeged, Szeged, Hungary., Solymár M; Institute for Translational Medicine, University of Pécs Medical School, Pécs, Hungary., Tenk J; Institute for Translational Medicine, University of Pécs Medical School, Pécs, Hungary., Ottóffy M; Institute for Translational Medicine, University of Pécs Medical School, Pécs, Hungary., Nagy A; Department for Pediatrics, University of Pécs Medical School, Pécs, Hungary., Habon T; Division of Cardiology, 1st Department of Medicine, University of Pécs Medical School, Pécs, Hungary., Hegyi P; Institute for Translational Medicine, University of Pécs Medical School, Pécs, Hungary., Czopf L; Division of Cardiology, 1st Department of Medicine, University of Pécs Medical School, Pécs, Hungary. laszlo.czopf@aok.pte.hu.; Division of Cardiology, 1st Department of Medicine, University of Pécs Medical School, Ifjúság u. 13., Pécs, H-7624, Hungary. laszlo.czopf@aok.pte.hu. |
| Abstrakt: |
Studies on the effectiveness of ultrafiltration (UF) in patients hospitalized with acute decompensated heart failure (ADHF) have led to heterogeneous study outcomes. This meta-analysis aimed to assess the impact of UF therapy in ADHF patients. We searched the medical literature to identify well-designed studies comparing UF with the usual diuretic therapy in this setting. Systematic evaluation of 8 randomized controlled trials enrolling 801 participants showed greater fluid removal (difference in means 1372.5 mL, 95% CI 849.6 to 1895.4 mL; p < 0.001), weight loss (difference in means 1.592 kg, 95% CI 1.039 to 2.144 kg; p < 0.001) and lower incidences of worsening heart failure (OR 0.63, 95% CI 0.43 to 0.94, p = 0.022) and rehospitalization for heart failure (OR 0.54, 95% CI 0.36 to 0.82, p = 0.003) without a difference in renal impairment (OR 1.386, 95% CI 0.870 to 2.209; p = 0.169) or all-cause mortality (OR 1.13, 95% CI 0.75 to 1.71, p = 0.546). UF increases fluid removal and weight loss and reduces rehospitalization and the risk of worsening heart failure in congestive patients, suggesting ultrafiltration as a safe and effective treatment option for volume-overloaded heart failure patients. |
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