Is long-bout sedentary behaviour associated with long-term glucose levels 3 months after acute ischaemic stroke? A prospective observational cohort study.

Autor:	Alme KN; Department of Clinical Medicine (K1), University of Bergen, Bergen, Norway katinka.alme@gmail.com.; Department of Internal Medicine, Haraldsplass Deaconess Hospital, Bergen, Norway.; Kavli Research Centre for Geriatrics and Dementia, Haraldsplass Deaconess Hospital, Bergen, Norway., Knapskog AB; Department of Geriatric Medicine, Oslo University Hospital Ullevaal, Oslo, Norway., Næss H; Department of Clinical Medicine (K1), University of Bergen, Bergen, Norway.; Department of Neurology, Haukeland University Hospital, Bergen, Norway.; Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger, Norway., Naik M; Department of Internal Medicine, Haraldsplass Deaconess Hospital, Bergen, Norway.; Department of Clinical Science (K2), University of Bergen, Bergen, Norway., Beyer M; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway., Ellekjaer H; Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.; Stroke Unit, Clinic of Internal Medicine, Saint Olavs Hospital University Hospital, Trondheim, Norway., English C; Division of Health Sciences, International Centre for Allied health Evidence, University of South Australia Division of Health Sciences, Adelaide, South Australia, Australia.; Stroke Division, The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia., Hansen HI; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Neurology, Oslo University Hospital, Oslo, Norway., Kummeneje CS; Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway., Munthe-Kaas R; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Medicine, Vestre Viken Hospital Trust, Drammen, Norway., Saltvedt I; Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Geriatrics, Clinic of Internal Medicine, Saint Olavs Hospital University Hospital, Trondheim, Norway., Seljeseth Y; Department of Internal Medicine, Aalesund Hospital, Alesund, Norway., Tan X; Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway., Thingstad P; Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway., Askim T; Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
Jazyk:	angličtina
Zdroj:	BMJ open [BMJ Open] 2020 Nov 26; Vol. 10 (11), pp. e037475. Date of Electronic Publication: 2020 Nov 26.
DOI:	10.1136/bmjopen-2020-037475
Abstrakt:	Background and Purpose: Sedentary behaviour is a risk factor for vascular disease and stroke patients are more sedentary than their age-matched peers. The association with glucose levels, as a potential mediator, is unclear, and we have investigated the association between long-bout sedentary behaviour and long-term glucose levels in stroke survivors. Methods: This study uses data from the Norwegian Cognitive Impairment After Stroke study, a multicentre cohort study. The patients were recruited at hospital admission for acute stroke, and the follow-up was done at the outpatient clinic. Sedentary behaviour-being in a sitting or reclining position-was registered 3 months after stroke using position transition data from the body-worn sensor activPAL attached to the unaffected thigh. A MATLAB script was developed to extract activity data from 08:00 to 10:00 for 4 days and to categorise the data into four bout-length categories. The primary outcome was glycated haemoglobin (HbA1c), analysed at 3 months. Regression models were used to analyse the association between HbA1c and sedentary behaviour in the whole population and stratified based on a diagnosis of diabetes mellitus (DM). Age, body mass index and the use of antidiabetic drugs were added as covariates into the models. Results: From a total of 815 included patients, 379 patients fulfilled the inclusion criteria for this study. We found no association between time in sedentary behaviour and HbA1c in the whole stroke population. We found time in sedentary behaviour in bouts of ≥90 min to be associated with a higher HbA1c in patients with DM. Conclusion: Long-bout sedentary time is associated with a higher HbA1c in patients with DM 3 months after ischaemic stroke. Future research should investigate the benefit of breaking up sedentary time as a secondary preventive measure. Trial Registration Number: NCT02650531, https://clinicaltrials.gov/ct2/show/NCT02650531. Competing Interests: Competing interests: A-BK: principal investigator in two drug trials (Roche BN29553 and Boehringer-Ingelheim 1346-0023) at the memory clinic, Oslo University Hospital. Others: none declared. (© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.)
Databáze:	MEDLINE
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