Newly emerged resistance-breaking variants of cucumber mosaic virus represent ongoing host-interactive evolution of an RNA virus.

Autor:	Heo KJ; Department of International Agricultural Technology., Kwon SJ; Institutes of Green Bio Science and Technology, Seoul National University, 1447 Pyeongchang-ro, Pyeongchang 25354, Republic of Korea., Kim MK; Department of Plant Medicine, Chungbuk National University, 1 Chungdae-ro, Cheongju 28644, Republic of Korea., Kwak HR; Crop Protection Division, National Institute of Agricultural Sciences, Rural Development Administration, 300 Nongsaengmyeong-ro, Wanju 55365, Republic of Korea., Han SJ; Department of International Agricultural Technology., Kwon MJ; Department of International Agricultural Technology., Rao ALN; Department of Microbiology and Plant Pathology, University of California, Boyce Hall 1463, 900 University Ave, Riverside, CA 92521, USA., Seo JK; Department of International Agricultural Technology.
Jazyk:	angličtina
Zdroj:	Virus evolution [Virus Evol] 2020 Nov 07; Vol. 6 (2), pp. veaa070. Date of Electronic Publication: 2020 Nov 07 (Print Publication: 2020).
DOI:	10.1093/ve/veaa070
Abstrakt:	Understanding the evolutionary history of a virus and the mechanisms influencing the direction of its evolution is essential for the development of more durable strategies to control the virus in crop fields. While the deployment of host resistance in crops is the most efficient means to control various viruses, host resistance itself can act as strong selective pressure and thus play a critical role in the evolution of virus virulence. Cucumber mosaic virus (CMV), a plant RNA virus with high evolutionary capacity, has caused endemic disease in various crops worldwide, including pepper ( Capsicum annuum L.), because of frequent emergence of resistance-breaking variants. In this study, we examined the molecular and evolutionary characteristics of recently emerged, resistance-breaking CMV variants infecting pepper. Our population genetics analysis revealed that the high divergence capacity of CMV RNA1 might have played an essential role in the host-interactive evolution of CMV and in shaping the CMV population structure in pepper. We also demonstrated that nonsynonymous mutations in RNA1 encoding the 1a protein enabled CMV to overcome the deployed resistance in pepper. Our findings suggest that resistance-driven selective pressures on RNA1 might have contributed in shaping the unique evolutionary pattern of CMV in pepper. Therefore, deployment of a single resistance gene may reduce resistance durability against CMV and more integrated approaches are warranted for successful control of CMV in pepper. (© The Author(s) 2020. Published by Oxford University Press.)
Databáze:	MEDLINE
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