Lower Cardiac Output Relates to Longitudinal Cognitive Decline in Aging Adults.

Autor:	Bown CW; Vanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, United States., Do R; Vanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.; Vanderbilt University School of Medicine, Vanderbilt University, Nashville, TN, United states., Khan OA; Vanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, United States., Liu D; Vanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, United States., Cambronero FE; Vanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, United States., Moore EE; Vanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, United States.; Vanderbilt University School of Medicine, Vanderbilt University, Nashville, TN, United states., Osborn KE; Vanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States., Gupta DK; Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.; Vanderbilt Heart Imaging Core Lab, Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University Medical Center, Nashville, TN, United States., Pechman KR; Vanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States., Mendes LA; Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States., Hohman TJ; Vanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, United States.; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, United States., Gifford KA; Vanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States., Jefferson AL; Vanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, United States.; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in psychology [Front Psychol] 2020 Nov 09; Vol. 11, pp. 569355. Date of Electronic Publication: 2020 Nov 09 (Print Publication: 2020).
DOI:	10.3389/fpsyg.2020.569355
Abstrakt:	Background: Subclinical reductions in cardiac output correspond to lower cerebral blood flow (CBF), placing the brain at risk for functional changes. Objectives: This study aims to establish the consequences of reduced cardiac output on longitudinal cognitive outcomes in aging adults. Methods: Vanderbilt Memory and Aging Project participants free of clinical dementia and heart failure ( n = 306, 73 ± 7, 58% male) underwent baseline echocardiography to assess cardiac output (L/min) and longitudinal neuropsychological assessment at baseline, 18 months, 3 and 5 years. Linear mixed-effects regressions related cardiac output to trajectory for each longitudinal neuropsychological outcome, adjusting for age, sex, race/ethnicity, education, body surface area, Framingham Stroke Risk Profile score, apolipoprotein E ( APOE ) ε4 status and follow-up time. Models were repeated, testing interactions with cognitive diagnosis and APOE- ε4 status. Results: Lower baseline cardiac output related to faster declines in language (β = 0.11, p = 0.01), information processing speed (β = 0.31, p = 0.006), visuospatial skills (β = 0.09, p = 0.03), and episodic memory (β = 0.02, p = 0.001). No cardiac output x cognitive diagnosis interactions were observed ( p > 0.26). APOE -ε4 status modified the association between cardiac output and longitudinal episodic memory (β = 0.03, p = 0.047) and information processing speed outcomes (β = 0.55, p = 0.02) with associations stronger in APOE- ε4 carriers. Conclusion: The present study provides evidence that even subtle reductions in cardiac output may be associated with more adverse longitudinal cognitive health, including worse language, information processing speed, visuospatial skills, and episodic memory performances. Preservation of healthy cardiac functioning is important for maintaining optimal brain aging among older adults. (Copyright © 2020 Bown, Do, Khan, Liu, Cambronero, Moore, Osborn, Gupta, Pechman, Mendes, Hohman, Gifford and Jefferson.)
Databáze:	MEDLINE
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