The relationship among androgens, insulin resistance and ghrelin polymorphisms in post-adolescent male patients with severe acne vulgaris.

Autor:	Pektas SD; Department of Dermatology, Faculty of Medicine, Mugla Sitki Kocman University, Mugla, Turkey., Cinar N; Department of Endocrinology and Metabolic Diseases, Faculty of Medicine, Mugla Sitki Kocman University, Mugla, Turkey., Duman DD; Department of Dermatology, Acibadem University, Istanbul, Turkey., Kara A; Department of Family Medicine, Faculty of Medicine, Mugla Sitki Kocman University, Mugla, Turkey., Batu J; Department of Biochemistry, SYNLAB, Ankara, Turkey., Karakas-Celik S; Department of Molecular Biology and Genetic, Faculty of Science, Bulent Ecevit University, Zonguldak, Turkey., Aksoy DY; Department of Internal Medicine, Acibadem University, Istanbul, Turkey.
Jazyk:	angličtina
Zdroj:	Postepy dermatologii i alergologii [Postepy Dermatol Alergol] 2020 Oct; Vol. 37 (5), pp. 800-809. Date of Electronic Publication: 2020 Nov 07.
DOI:	10.5114/ada.2020.100492
Abstrakt:	Introduction: Ghrelin has anti-inflammatory and immunomodulatory activities. Data about the role of ghrelin and ghrelin polymorphisms in the development of acne vulgaris in post-adolescent male patients are limited. Aim: To evaluate the role of serum androgens, insulin resistance, ghrelin and ghrelin polymorphisms in severe acne vulgaris. Material and Methods: Thirty-five post-adolescent male patients with a mean age of 28.0 ±5.4 years and 33 age-and BMI-matched controls were enrolled. Serum androgens, lipids, insulin sensitivity parameters and ghrelin levels were determined. The PCR method was used for GHRL polymorphisms (rs27647, rs696217 and rs34911341 genotypes). Results: Patients had similar anthropometric measures to controls, except a significantly higher WHR in patients (0.92 ±0.06 vs. 0.86 ±0.08, p < 0.05). Also, FPG, HOMA-IR values, lipid profile and serum androgen levels were similar. Interestingly, patients had significantly lower ghrelin levels than controls (4.5 ±5.8 vs. 101.2 ±86.5 pg/ml, p < 0.001). The frequencies of rs696217 and rs34911341 genotypes were similar whereas the distribution of rs27647 alleles was significantly different between the groups ( p < 0.05). GA and GG genotypes of GHRL rs27647 polymorphism indicated an increased risk of developing acne vulgaris (OR = 11.156, 95% CI: 2.864-43.464, OR = 5.312, 95% CI: 1.269-22.244, respectively; p < 0.05). Patients with rs27647-AA polymorphism had significantly lower GAGS scores than other groups (AA genotype 6.7 ±14.1 vs. GA genotype 24.6 ±15.7 and GG genotype 19.4 ±17.9, p < 0.001). None of the polymorphisms had a significant effect on metabolic parameters, insulin sensitivity and serum ghrelin levels. Conclusions: Decreased ghrelin levels and GA and GG genotypes of GHRL gene rs27647 polymorphism may have a role in the pathogenesis of acne vulgaris. Competing Interests: The authors declare no conflict of interest. (Copyright © 2020 Termedia.)
Databáze:	MEDLINE
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