Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women.

Autor: Steinthorsdottir V; deCODE genetics/Amgen Inc., Reykjavik, Iceland. valgerdur.steinthorsdottir@decode.is., McGinnis R; Wellcome Sanger Institute, Cambridge, UK. rm2@sanger.ac.uk., Williams NO; Wellcome Sanger Institute, Cambridge, UK., Stefansdottir L; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Thorleifsson G; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Shooter S; Wellcome Sanger Institute, Cambridge, UK., Fadista J; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.; Department of Clinical Sciences, Lund University Diabetes Centre, Malmö, Sweden., Sigurdsson JK; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Auro KM; Finnish Institute for Health and Welfare, Helsinki, Finland., Berezina G; Scientific Center of Obstetrics, Gynecology and Perinatology, Almaty, Kazakhstan., Borges MC; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK., Bumpstead S; Wellcome Sanger Institute, Cambridge, UK., Bybjerg-Grauholm J; Department for Congenital Disorders, Danish Centre for Neonatal Screening, Statens Serum Institut, Copenhagen, Denmark., Colgiu I; Wellcome Sanger Institute, Cambridge, UK., Dolby VA; Leeds Institute of Medical Research (LIMR), School of Medicine, University of Leeds, Leeds, UK., Dudbridge F; Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK., Engel SM; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Franklin CS; Wellcome Sanger Institute, Cambridge, UK., Frigge ML; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Frisbaek Y; Department of Obstetrics and Gynecology, Landspitali University Hospital, Reykjavik, Iceland., Geirsson RT; Department of Obstetrics and Gynecology, Landspitali University Hospital, Reykjavik, Iceland., Geller F; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Gretarsdottir S; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Gudbjartsson DF; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland., Harmon Q; Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, NC, USA., Hougaard DM; Department for Congenital Disorders, Danish Centre for Neonatal Screening, Statens Serum Institut, Copenhagen, Denmark., Hegay T; Institute of immunology and human genomics, Uzbek Academy of Sciences, Tashkent, Uzbekistan., Helgadottir A; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Hjartardottir S; Department of Obstetrics and Gynecology, Landspitali University Hospital, Reykjavik, Iceland., Jääskeläinen T; Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Johannsdottir H; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Jonsdottir I; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Juliusdottir T; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Kalsheker N; School of Life Sciences, University of Nottingham, Nottingham, UK., Kasimov A; Institute of immunology and human genomics, Uzbek Academy of Sciences, Tashkent, Uzbekistan., Kemp JP; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD, Australia., Kivinen K; Division of Cardiovascular Medicine, University of Cambridge, Cambridge, UK., Klungsøyr K; Division of Mental and Physical Health, Norwegian Institute of Public Health, Oslo, Norway.; Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway., Lee WK; Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK., Melbye M; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Miedzybrodska Z; Division of Applied Medicine, School of Medicine, Medical Sciences, Nutrition and Dentistry, University of Aberdeen, Aberdeen, UK., Moffett A; Department of Pathology, University of Cambridge, Cambridge, UK., Najmutdinova D; Republic Specialized Scientific Practical Medical Centre of Obstetrics and Gynecology, Tashkent, Uzbekistan., Nishanova F; Republic Specialized Scientific Practical Medical Centre of Obstetrics and Gynecology, Tashkent, Uzbekistan., Olafsdottir T; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Perola M; Finnish Institute for Health and Welfare, Helsinki, Finland.; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Pipkin FB; School of Medicine, University of Nottingham, Nottingham, UK., Poston L; Department of Women and Children's Health, King's College London, London, UK., Prescott G; Division of Applied Medicine, School of Medicine, Medical Sciences, Nutrition and Dentistry, University of Aberdeen, Aberdeen, UK.; Lancashire Clinical Trials Unit, University of Central Lancashire, Preston, UK., Saevarsdottir S; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Salimbayeva D; Scientific Center of Obstetrics, Gynecology and Perinatology, Almaty, Kazakhstan., Scaife PJ; School of Medicine, University of Nottingham, Nottingham, UK., Skotte L; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Staines-Urias E; Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK., Stefansson OA; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Sørensen KM; The Danish National Biobank, Statens Serum Institut, Copenhagen, Danmark., Thomsen LCV; Department of Clinical Science, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway.; Department of Clinical and Molecular Medicine, Centre of Molecular Inflammation Research (CEMIR), Norwegian University of Science and Technology (NTNU), Trondheim, Norway., Tragante V; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Division Heart & Lungs, Department of Cardiology, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands., Trogstad L; Department of Infectious Disease Epidemiology and Modelling, Norwegian Institute of Public Health, Oslo, Norway., Simpson NAB; Division of Womens and Children's Health, School of Medicine, University of Leeds, Leeds, UK., Aripova T; Institute of immunology and human genomics, Uzbek Academy of Sciences, Tashkent, Uzbekistan., Casas JP; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Dominiczak AF; Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK., Walker JJ; Leeds Institute of Medical Research (LIMR), School of Medicine, University of Leeds, Leeds, UK., Thorsteinsdottir U; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Iversen AC; Department of Clinical and Molecular Medicine, Centre of Molecular Inflammation Research (CEMIR), Norwegian University of Science and Technology (NTNU), Trondheim, Norway., Feenstra B; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Lawlor DA; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK.; Bristol NIHR Biomedical Research Centre, Bristol, UK., Boyd HA; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Magnus P; Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway., Laivuori H; Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.; Department of Obstetrics and Gynecology, Tampere University Hospital and Tampere University, Faculty of Medicine and Health Technology, Tampere, Finland., Zakhidova N; Institute of immunology and human genomics, Uzbek Academy of Sciences, Tashkent, Uzbekistan., Svyatova G; Scientific Center of Obstetrics, Gynecology and Perinatology, Almaty, Kazakhstan., Stefansson K; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Morgan L; School of Life Sciences, University of Nottingham, Nottingham, UK.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2020 Nov 25; Vol. 11 (1), pp. 5976. Date of Electronic Publication: 2020 Nov 25.
DOI: 10.1038/s41467-020-19733-6
Abstrakt: Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia.
Databáze: MEDLINE