Methemoglobinemia and hemolytic anemia after COVID-19 infection without identifiable eliciting drug: A case-report.

Autor:	Lopes DV; Department of Internal Medicine, Hospital Dr. Moyses Deustche (Mboi Mirim), Estrada do Mboi Mirim, 5203, São Paulo, Brazil., Lazar Neto F; Department of Internal Medicine, Hospital Dr. Moyses Deustche (Mboi Mirim), Estrada do Mboi Mirim, 5203, São Paulo, Brazil.; Department of Internal Medicine, Faculdade de Medicina da Universidade de São Paulo (FMUSP), Av. Dr. Enéas Carvalho de Aguiar, 155, São Paulo, Brazil., Marques LC; Department of Internal Medicine, Hospital Dr. Moyses Deustche (Mboi Mirim), Estrada do Mboi Mirim, 5203, São Paulo, Brazil., Lima RBO; Department of Internal Medicine, Hospital Dr. Moyses Deustche (Mboi Mirim), Estrada do Mboi Mirim, 5203, São Paulo, Brazil., Brandão AAGS; Department of Hematology, Hospital A Beneficência Portuguesa de São Paulo (BP), R. Maestro Cardim, 769, São Paulo, Brazil.
Jazyk:	angličtina
Zdroj:	IDCases [IDCases] 2021; Vol. 23, pp. e01013. Date of Electronic Publication: 2020 Nov 19.
DOI:	10.1016/j.idcr.2020.e01013
Abstrakt:	We report a second case of methemoglobinemia and non-autoimmune hemolytic anemia after contracting the SARS-CoV-2 infection in the absence of an identifiable eliciting drug. A 35-year old male without previous known comorbidities was admitted after he was diagnosed with the COVID-19 infection and had large pulmonary involvement. Seven days later, he desaturated but was without any signs of respiratory distress. A check of arterial blood gas revealed normal partial pressure of oxygen and follow-up tests confirmed a methemoglobinemia diagnosis. Over the next few days, hemolysis was established after decreased levels of hemoglobin and increased levels of indirect bilirubin and lactate dehydrogenase. A hemolytic anemia investigation panel came back normal, including G6PD. A second G6PD test was ordered at the 5-month follow-up appointment and revealed decreased levels. Clinicians should thus be aware of possible false negative tests when testing for G6PD during hemolytic crisis. In addition, whether the COVID-19 infection alone would be responsible for this chain of events remains a challenging question. (© 2020 The Authors.)
Databáze:	MEDLINE
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