Composition analysis of falsified chloroquine phosphate samples seized during the COVID-19 pandemic.

Autor: Waffo Tchounga CA; University of Liege (ULiege), CIRM, VibraSante Hub, Department of Pharmacy, Laboratory of Pharmaceutical Analytical Chemistry, Liege, Belgium; University of Yaoundé I, Faculty of Medicine and Biomedical Sciences, Cameroon., Sacre PY; University of Liege (ULiege), CIRM, VibraSante Hub, Department of Pharmacy, Laboratory of Pharmaceutical Analytical Chemistry, Liege, Belgium. Electronic address: pysacre@uliege.be., Ciza P; University of Liege (ULiege), CIRM, VibraSante Hub, Department of Pharmacy, Laboratory of Pharmaceutical Analytical Chemistry, Liege, Belgium; University of Kinshasa, Faculty of Pharmaceutical Sciences, LACOMEDA, Lemba, 212 Kinshasa XI, Democratic Republic of Congo., Ngono R; University of Yaoundé I, Faculty of Medicine and Biomedical Sciences, Cameroon; National Drug Control and Valuation (LANACOME), Yaoundé, Cameroon., Ziemons E; University of Liege (ULiege), CIRM, VibraSante Hub, Department of Pharmacy, Laboratory of Pharmaceutical Analytical Chemistry, Liege, Belgium., Hubert P; University of Liege (ULiege), CIRM, VibraSante Hub, Department of Pharmacy, Laboratory of Pharmaceutical Analytical Chemistry, Liege, Belgium., Marini RD; University of Liege (ULiege), CIRM, VibraSante Hub, Department of Pharmacy, Laboratory of Pharmaceutical Analytical Chemistry, Liege, Belgium.
Jazyk: angličtina
Zdroj: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2021 Feb 05; Vol. 194, pp. 113761. Date of Electronic Publication: 2020 Nov 12.
DOI: 10.1016/j.jpba.2020.113761
Abstrakt: The proliferation of falsified medicines can cause serious public health issues, particularly in the context of a global pandemic such as the actual COVID-19 pandemic. Our study involved eight chloroquine phosphate medicines seized in Cameroon, Democratic Republic of Congo and Niger during March and May 2020. These suspect samples were first analyzed in a screening phase using field tools such as handheld Raman spectroscopy (TruScan) and then in a confirmation phase using laboratory tools such as hyperspectral Raman imaging and High Performance Liquid Chromatography (HPLC). The results confirmed the falsified nature of the samples, highlighting the presence of metronidazole at low dose in four samples (16.6, 15.2, 15.2 and 14.5 mg/tab), too low levels of chloroquine in two samples (2.4 and 20.2 mg/tab), and substitution of chloroquine phosphate by paracetamol in one sample (255.7 mg/tab). The results also confirmed that four samples had been adulterated with paracetamol in trace amounts and two of them presented traces of chloramphenicol.
Competing Interests: Declaration of Competing Interest The authors report no declarations of interest.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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