Extracellular Vesicle-Mediated Bilateral Communication between Glioblastoma and Astrocytes.

Autor: Nieland L; Departments of Neurology and Radiology, Massachusetts General Hospital, and NeuroDiscovery Center, Harvard Medical School, Boston, MA, 02129, USA., Morsett LM; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02129, USA., Broekman MLD; Departments of Neurology and Radiology, Massachusetts General Hospital, and NeuroDiscovery Center, Harvard Medical School, Boston, MA, 02129, USA; Department of Neurosurgery, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands; Department of Neurosurgery, Haaglanden Medical Center, 2512 VA, The Hague, The Netherlands., Breakefield XO; Departments of Neurology and Radiology, Massachusetts General Hospital, and NeuroDiscovery Center, Harvard Medical School, Boston, MA, 02129, USA., Abels ER; Departments of Neurology and Radiology, Massachusetts General Hospital, and NeuroDiscovery Center, Harvard Medical School, Boston, MA, 02129, USA; Department of Neurosurgery, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands. Electronic address: eabels@mgh.harvard.edu.
Jazyk: angličtina
Zdroj: Trends in neurosciences [Trends Neurosci] 2021 Mar; Vol. 44 (3), pp. 215-226. Date of Electronic Publication: 2020 Nov 21.
DOI: 10.1016/j.tins.2020.10.014
Abstrakt: Glioblastoma the most aggressive form of brain cancer, comprises a complex mixture of tumor cells and nonmalignant stromal cells, including neurons, astrocytes, microglia, infiltrating monocytes/macrophages, lymphocytes, and other cell types. All nonmalignant cells within and surrounding the tumor are affected by the presence of glioblastoma. Astrocytes use multiple modes of communication to interact with neighboring cells. Extracellular vesicle-directed intercellular communication has been found to be an important component of signaling between astrocytes and glioblastoma in tumor progression. In this review, we focus on recent findings on extracellular vesicle-mediated bilateral crosstalk, between glioblastoma cells and astrocytes, highlighting the protumor and antitumor roles of astrocytes in glioblastoma development.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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