Neurological Findings in Children without Congenital Microcephaly Exposed to Zika Virus in Utero: A Case Series Study.

Autor: Abtibol-Bernardino MR; Postgraduate Program in Tropical Medicine, University of Amazonas State, Manaus 69040-000, Brazil., de Almeida Peixoto LFA; Postgraduate Program in Tropical Medicine, University of Amazonas State, Manaus 69040-000, Brazil., de Oliveira GA; Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus 69040-000, Brazil., de Almeida TF; Department of Medicine, Federal University of Amazonas, Manaus 69067-005, Brazil., Rodrigues GRI; Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus 69040-000, Brazil., Otani RH; Department of Medicine, School of Health Sciences, University of Amazonas State, Manaus 69065-001, Brazil., Soares Chaves BC; Postgraduate Program in Tropical Medicine, University of Amazonas State, Manaus 69040-000, Brazil., de Souza Rodrigues C; Postgraduate Program in Tropical Medicine, University of Amazonas State, Manaus 69040-000, Brazil., de Andrade ABCA; Postgraduate Program in Living Conditions and Health Situations in the Amazon PPGVIDA, Leônidas & Maria Deane Institute, Fiocruz Amazonia, Manaus 69057-070, Brazil., de Fatima Redivo E; Postgraduate Program in Tropical Medicine, University of Amazonas State, Manaus 69040-000, Brazil., Fernandes SS; Postgraduate Program in Tropical Medicine, University of Amazonas State, Manaus 69040-000, Brazil., da Costa Castilho M; Department of Virology, Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus 69040-000, Brazil., Gomes Benzecry S; Department of Medicine, School of Health Sciences, University of Amazonas State, Manaus 69065-001, Brazil., Bôtto-Menezes C; Postgraduate Program in Tropical Medicine, University of Amazonas State, Manaus 69040-000, Brazil.; Department of Medicine, School of Health Sciences, University of Amazonas State, Manaus 69065-001, Brazil.; Department of Malaria, Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus 69040-000, Brazil., Martinez-Espinosa FE; Postgraduate Program in Tropical Medicine, University of Amazonas State, Manaus 69040-000, Brazil.; Postgraduate Program in Living Conditions and Health Situations in the Amazon PPGVIDA, Leônidas & Maria Deane Institute, Fiocruz Amazonia, Manaus 69057-070, Brazil.; Department of Malaria, Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus 69040-000, Brazil.; Laboratory of Territory, Environment, Health and Sustainability, Leônidas & Maria Deane Institute, Fiocruz Amazonia, Manaus 69057-070, Brazil., Costa Alecrim MDG; Postgraduate Program in Tropical Medicine, University of Amazonas State, Manaus 69040-000, Brazil.; Department of Malaria, Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus 69040-000, Brazil.; Medical Course Coordination, Manaus Metropolitan College/FAMETRO, Manaus 69050-000, Brazil.
Jazyk: angličtina
Zdroj: Viruses [Viruses] 2020 Nov 20; Vol. 12 (11). Date of Electronic Publication: 2020 Nov 20.
DOI: 10.3390/v12111335
Abstrakt: The Zika virus can induce a disruptive sequence in the fetal brain and is manifested mainly by microcephaly. Knowledge gaps still exist as to whether the virus can cause minor disorders that are perceived later on during the first years of life in children who are exposed but are asymptomatic at birth. In this case series, we describe the outcomes related to neurodevelopment through the neurological assessment of 26 non-microcephalic children who had intrauterine exposure to Zika virus. Children were submitted for neurological examinations and Bayley Scales-III (cognition, language, and motor performance). The majority (65.4%) obtained satisfactory performance in neurodevelopment. The most impaired domain was language, with 30.7% impairment. Severe neurological disorders occurred in five children (19.2%) and these were spastic hemiparesis, epilepsy associated with congenital macrocephaly (Zika and human immunodeficiency virus), two cases of autism (one exposed to Zika and Toxoplasma gondii ) and progressive sensorineural hearing loss ( GJB2 mutation). We concluded that non-microcephalic children with intrauterine exposure to Zika virus, in their majority, had achieved satisfactory performance in all neurodevelopmental domains. One third of the cases had some impairment, but the predominant group had mild alterations, with low occurrence of moderate to severe disorders, similar to other studies in Brazil.
Databáze: MEDLINE
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