Multi-wavelength, handheld laser speckle imaging for skin evaluation.
| Autor: | Zieger M; SRH Wald-Klinikum Gera GmbH, Zentrum für klinische Studien, Gera, Germany., Kaatz M; SRH Wald-Klinikum Gera GmbH, Zentrum für klinische Studien, Gera, Germany., Springer S; SRH Wald-Klinikum Gera GmbH, Zentrum für klinische Studien, Gera, Germany.; Universitätsklinikum Jena, Jena, Germany., Riesenberg R; Leibniz-Institut für Photonische Technologien e.V. Jena, Jena, Germany., Wuttig A; Codion Optics, Jena, Germany., Kanka M; Leibniz-Institut für Photonische Technologien e.V. Jena, Jena, Germany., Stanca S; Leibniz-Institut für Photonische Technologien e.V. Jena, Jena, Germany., Reble C; Courage+Khazaka Electronic GmbH, Köln, Germany., Khazaka G; Courage+Khazaka Electronic GmbH, Köln, Germany., Sieg R; Beiersdorf AG, Applied Biophysics, Hamburg, Germany., De Gregorio M; Beiersdorf AG, Applied Biophysics, Hamburg, Germany., Sattler M; Beiersdorf AG, Applied Biophysics, Hamburg, Germany., Fischer F; Beiersdorf AG, Applied Biophysics, Hamburg, Germany. |
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| Jazyk: | angličtina |
| Zdroj: | Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) [Skin Res Technol] 2021 Jul; Vol. 27 (4), pp. 486-493. Date of Electronic Publication: 2020 Nov 24. |
| DOI: | 10.1111/srt.12959 |
| Abstrakt: | Objective: A handheld device was developed and qualified for in vivo human skin evaluation using laser speckle imaging technology. Methods: Each laser speckle device prototype allows the choice of up to three different laser wavelengths in the range of 400 nm to 800 nm in total. Speckle pattern analysis gives various speckle parameters, for example, speckle contrast, speckle size, speckle modulation or fractal dimension. The developed laser speckle device prototypes were evaluated investigating three skin issues. Results: We receive reproducible results from the speckle imaging device. For skin ageing, we found significant changes within three age groups. The effect of a methyl nicotinate treatment was clearly visible and quantifiable using a moorFLPI device as well as our speckle imaging device. In terms of basal cell carcinoma diagnosis, we found significant differences between normal and diseased skin, even though the number of samples was limited. Conclusion: As shown with first application examples, it was possible to demonstrate the potential of the method for skin evaluation in vivo. (© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.) |
| Databáze: | MEDLINE |
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