Respiratory Complications of Pediatric Neuromuscular Diseases.
| Autor: | Bach JR; Department of Physical Medicine and Rehabilitation, Rutgers University, New Jersey Medical School, Newark, NJ, USA. Electronic address: bachjr@njms.rutgers.edu., Turcios NL; Hackensack Meridian School of Medicine, Nutley, NJ 07110, USA., Wang L; Department of Neurology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing 100191, China. |
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| Jazyk: | angličtina |
| Zdroj: | Pediatric clinics of North America [Pediatr Clin North Am] 2021 Feb; Vol. 68 (1), pp. 177-191. |
| DOI: | 10.1016/j.pcl.2020.09.006 |
| Abstrakt: | Respiration is an event of oxygen consumption and carbon dioxide production. Respiratory failure is common in pediatric neuromuscular diseases and the main cause of morbidity and mortality. It is a consequence of lung failure, ventilatory pump failure, or their combination. Lung failure often is due to chronic aspiration either from above or from below. It may lead to end-stage lung disease. Ventilatory pump failure is caused by increased respiratory load and progressive respiratory muscles weakness. This article reviews the normal function of the respiratory pump, general pathophysiology issues, abnormalities in the more common neuromuscular conditions and noninvasive interventions. Competing Interests: Disclosure The authors have nothing to disclose. (Copyright © 2020 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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