A comparison of two hyperbaric oxygen regimens: 2.0 ATA for 120 minutes to 2.4 ATA for 90 minutes in treating radiation-induced cystitis Are these regimens equivalent?

Autor:	Ajayi OD; Division of Hyperbaric Medicine, Department of Emergency Medicine, Hennepin Healthcare, Minneapolis, Minnesota U.S., Gaskill Z; Division of Hyperbaric Medicine, Department of Emergency Medicine, University of Pennsylvania, Philadelphia, Pennsylvania U.S., Kelly M; Division of Hyperbaric Medicine, Department of Emergency Medicine, University of Pennsylvania, Philadelphia, Pennsylvania U.S., Logue CJ; Division of Hyperbaric Medicine, Department of Emergency Medicine, Hennepin Healthcare, Minneapolis, Minnesota U.S.; University of Minnesota Medical School, Minneapolis, Minnesota U.S., Hendricksen SM; Division of Hyperbaric Medicine, Department of Emergency Medicine, Hennepin Healthcare, Minneapolis, Minnesota U.S.; University of Minnesota Medical School, Minneapolis, Minnesota U.S.
Jazyk:	angličtina
Zdroj:	Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc [Undersea Hyperb Med] 2020 Fourth Quarter; Vol. 47 (4), pp. 581-589.
DOI:	10.22462/10.12.2020.7
Abstrakt:	Introduction: Hyperbaric oxygen dosing variations exist in radiation cystitis treatment. The objectives of this study were to compare response and safety rates among patients with radiation cystitis treated with different protocols: 2.0 ATA (atmospheres absolute) for 120 minutes at the University of Pennsylvania; and 2.4 ATA for 90 minutes at Hennepin Healthcare. Materials and Methods: Retrospective chart review of radiation cystitis patients treated with hyperbaric oxygen at the University of Pennsylvania (January 2010-December 2018) and Hennepin Healthcare Minnesota (January 2014-December 2018). Primary outcome was response to treatment. Complications were limited to hyperbaric-related conditions. Regression analysis was performed with ordinal logistic regression and binary logistic regression. Result: 126 patients were included in the analysis (2.0 ATA: 66, 2.4 ATA: 60). Overall response rate was 75.4% (good) and was not significantly different between protocols (good response: 2.0 ATA 72.7% vs. 2.4 ATA 78.3% p=0.74). The 2.0 ATA group required additional treatments [2.0 ATA: 45.45 ± 14.5 vs. 2.4 ATA: 40.03 ± 9.7, p<0.05]. 6.1% (2.0 ATA) and 13.3% (2.4 ATA) required tympanostomy tube placement or needle myringotomy for otic barotrauma (p=0.22). Transfusion was associated with poorer outcomes (p<0.05). Conclusion: Both groups - 2.0 ATA and 2.4 ATA - had similar response and complication rates. Blood transfusion is a negative prognostic factor for treatment outcome. Competing Interests: The authors of this paper declare no conflicts of interest exist with this submission. (Copyright© Undersea and Hyperbaric Medical Society.)
Databáze:	MEDLINE
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