Revisiting the pathogenic role of insulin resistance in Duchenne muscular dystrophy cardiomyopathy subphenotypes.
| Autor: | AbdelMassih AF; Pediatric Cardiology Unit, Department of Pediatrics, Faculty of Medicine, Cairo University.; Pediatric Cardio-oncology unit, Children Cancer Hospital of Egypt., Esmail R; Pediatric Cardiology Unit, Department of Pediatrics, Faculty of Medicine, Cairo University., Zekri H; Pediatric Cardiology Unit, Department of Pediatrics, Faculty of Medicine, Cairo University., Kharabish A; CMR Unit, Radiology department, Faculty of Medicine, Cairo University, Egypt.; CMR Unit, Radiology Department, Universitäts-Herzzentrum Freiburg-Bad Krozingen, Germany., ElKhashab K; Pediatric Endocrinology unit, Department of Pediatrics., Menshawey R; Students' Research Program, Faculty of Medicine, Cairo University., Ismail HA; Students' Research Program, Faculty of Medicine, Cairo University., Afdal P; Students' Research Program, Faculty of Medicine, Cairo University., Farid E; Department of Pediatrics., Affifi O; Pediatric Neurology Unit, Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt. |
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| Jazyk: | angličtina |
| Zdroj: | Cardiovascular endocrinology & metabolism [Cardiovasc Endocrinol Metab] 2020 May 18; Vol. 9 (4), pp. 165-170. Date of Electronic Publication: 2020 May 18 (Print Publication: 2020). |
| DOI: | 10.1097/XCE.0000000000000203 |
| Abstrakt: | Introduction: Duchenne muscular dystrophy (DMD) is known to impact the subepicardial layer of the myocardium through chronic inflammation. Recent animal studies have shown predominant subendocardial involvement in rats with DMD. The primary outcome parameter was to determine by cardiovascular MRI (CMR) if two differential patterns of myocardial involvements exist in DMD; the secondary outcome parameters were to correlate the observed pattern with metabolic markers such as insulin resistance measures. Methods: Forty patients with DMD were screened using CMR to determine which of them had predominantly subendocardial dysfunction (SENDO group), or subepicardial/midmyocardial involvement (SEPMI group). Patients were subjected to body mass index measurement, serum creatinine kinase, serum lactate dehydrogenase enzyme, fasting glucose-insulin ratio (FGIR), full lipid profile, left ventricular ejection fraction (LVEF), left ventricle E/E´ ratio (the ratio of early mitral inflow velocity to average early diastolic velocities of the basal septum and mitral annulus) for left ventricle diastolic function, and myocardial layer strain discriminating echocardiography (MLSD-STE). Results: 26 patients displayed SENDO while 34 displayed SEPMI. SENDO group displayed overt insulin resistance; (FGIR (SENDO: 7 ± 1 vs. SEPMI: 5 ± 1, P < 0.001). FGIR was negatively correlated with Subendocardial Global Longitudinal Strain (ENDO-LS) with r = -0.75. Conclusion: DMD does not seem to influence the heart uniformly; DMD cardiomyopathy probably has two separate phenotypes with different mechanisms. Insulin resistance might be implicated in its pathogenesis and its reversal may help to slow disease progression. Competing Interests: There are no conflicts of interest. (Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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