Modulation of pro-inflammatory and pro-resolution mediators by γ-linolenic acid: an important element in radioprotection against ionizing radiation.
| Autor: | Poorani R; Institute of Nuclear Medicine and Allied Sciences, DRDO, Delhi, India.; BioScience Research Centre and Department of Medicine, GVP Hospital and Medical College, Visakhapatnam, India., Bhatt AN; Institute of Nuclear Medicine and Allied Sciences, DRDO, Delhi, India., Das UN; BioScience Research Centre and Department of Medicine, GVP Hospital and Medical College, Visakhapatnam, India.; UND Life Sciences, Battle Ground, WA, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Archives of medical science : AMS [Arch Med Sci] 2020 Jan 29; Vol. 16 (6), pp. 1448-1456. Date of Electronic Publication: 2020 Jan 29 (Print Publication: 2020). |
| DOI: | 10.5114/aoms.2020.92469 |
| Abstrakt: | Introduction: The current study explored the radio-protective property of γ-linolenic acid (GLA) in C57BL/6J mice against low linear energy transfer ionizing radiation (IR; X-rays) and its modulatory effect on the production of lipid mediators such as prostaglandin E Methods: The effect of GLA pre-treatment on radiation induced inflammation was assessed by estimating plasma levels of high mobility group box 1 protein (HMGB1), TMOP/NO and various anti-oxidant enzymes. Results: γ-linolenic acid pre-treated mice exposed to lethal IR dose (7.5 Gy) showed a decrease in plasma levels of HMGB1, PGE2 and LXA4 and a fall in TMOP/NO ratio and improvement in anti-oxidant enzymes: catalase, glutathione transferase and glutathione peroxidase compared to IR mice, suggesting that GLA suppresses IR-induced inflammation and restores the pro- vs. anti-oxidant ratio to near normal, which could explain its radioprotective action. Conclusions: GLA showed radioprotective action. Competing Interests: The authors declare no conflict of interest. (Copyright: © 2020 Termedia & Banach.) |
| Databáze: | MEDLINE |
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