Fertility-Sparing Surgery for Early-Stage Cervical Cancer: A Systematic Review of the Literature.

Autor:	Kuznicki ML; Department of Gynecologic Oncology (Drs. Kuznicki, Chambers, Horowitz, and Crean-Tate) and Obstetrics and Gynecology (Drs. Morton and Son), Women's Health Institute, (Dr. Rose)., Chambers LM; Department of Gynecologic Oncology (Drs. Kuznicki, Chambers, Horowitz, and Crean-Tate) and Obstetrics and Gynecology (Drs. Morton and Son), Women's Health Institute, (Dr. Rose)., Morton M; Department of Gynecologic Oncology (Drs. Kuznicki, Chambers, Horowitz, and Crean-Tate) and Obstetrics and Gynecology (Drs. Morton and Son), Women's Health Institute, (Dr. Rose)., Son J; Department of Gynecologic Oncology (Drs. Kuznicki, Chambers, Horowitz, and Crean-Tate) and Obstetrics and Gynecology (Drs. Morton and Son), Women's Health Institute, (Dr. Rose)., Horowitz M; Department of Gynecologic Oncology (Drs. Kuznicki, Chambers, Horowitz, and Crean-Tate) and Obstetrics and Gynecology (Drs. Morton and Son), Women's Health Institute, (Dr. Rose)., Crean-Tate KK; Department of Gynecologic Oncology (Drs. Kuznicki, Chambers, Horowitz, and Crean-Tate) and Obstetrics and Gynecology (Drs. Morton and Son), Women's Health Institute, (Dr. Rose)., Hackett L; Library Services Education Institute (Ms. Hackett), Cleveland Clinic, Cleveland, Ohio., Rose PG; Department of Gynecologic Oncology (Drs. Kuznicki, Chambers, Horowitz, and Crean-Tate) and Obstetrics and Gynecology (Drs. Morton and Son), Women's Health Institute, (Dr. Rose). Electronic address: rosep@ccf.org.
Jazyk:	angličtina
Zdroj:	Journal of minimally invasive gynecology [J Minim Invasive Gynecol] 2021 Mar; Vol. 28 (3), pp. 513-526.e1. Date of Electronic Publication: 2020 Oct 24.
DOI:	10.1016/j.jmig.2020.10.013
Abstrakt:	Objective: This systematic review aimed to evaluate oncologic and reproductive outcomes after fertility-sparing surgery (FSS) for early-stage cervical cancer (early CC). Data Sources: Ovid MEDLINE, Ovid EMBASE, and Cochrane CENTRAL were searched from 1980 to the present using Medical Subject Headings terms; other controlled vocabulary terms; and keywords related to fertility, cervical cancer, and surgical techniques. Methods of Study Selection: A total of 2415 studies were screened, with 53 studies included. Studies reporting recurrences with a median follow-up of 12 months in early CC (International Federation of Gynecology and Obstetrics 2009 stages IA with lymphovascular space invasion, IB, or IIA) of traditional histologic type undergoing FSS were included. Tabulation, Integration, and Results: The studies were grouped by intervention, including vaginal radical trachelectomy (VRT), abdominal radical trachelectomy (ART), minimally invasive radical trachelectomy (MIS-RT), and conization or simple trachelectomy (ST), and studies involving neoadjuvant chemotherapy (NACT). Combined rates of recurrence (RR), cancer death (CDR), pregnancy (PR), and live birth (LBR) were calculated per procedure on the basis of all included studies that reported outcomes on that procedure. The results were as follows: VRT: RR 4%, CDR 1.7%, PR 49.4%, and LBR 65.0% ART: RR 3.9%, CDR 1.4%, PR 43.2%, and LBR 44.0% MIS-RT: RR 4.2%, CDR 0.7%, PR 36.2%, and LBR 57.1% Cone or ST: RR 4.2%, CDR 0.8%, PR 55.1%, and LBR 71.9% NACT: RR 7.5% and CDR 2.0% CONCLUSION: FSS of early CC with VRT, ART, or MIS-RT have comparable oncologic outcomes in carefully selected patients, with reproductive outcomes favoring VRT. Data on nonradical FSS with cone or ST are less robust but support similar oncologic outcomes to radical trachelectomy with fewer reproductive complications. NACT in this setting requires more investigation before routine implementation into practice. (Copyright © 2020 AAGL. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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