Uraemic Encephalopathy in a Persian Cat with Chronic Kidney Disease.

Autor: Machado M; Instituto Nacional de Investigación Agropecuaria, Tacuarembó, Uruguay., Wilson TM; Laboratory of Veterinary Pathology, College of Veterinary Medicine, University of Brasília, Brazil., Sousa DER; Laboratory of Veterinary Pathology, College of Veterinary Medicine, University of Brasília, Brazil., Gonçalves AAB; Laboratory of Veterinary Pathology, College of Veterinary Medicine, University of Brasília, Brazil., Martins CS; Veterinary Teaching Hospital,College of Veterinary Medicine,University of Brasília,Federal District,Brazil., Castro MB; Laboratory of Veterinary Pathology, College of Veterinary Medicine, University of Brasília, Brazil. Electronic address: mbcastro@unb.br.
Jazyk: angličtina
Zdroj: Journal of comparative pathology [J Comp Pathol] 2020 Oct; Vol. 180, pp. 100-104. Date of Electronic Publication: 2020 Oct 10.
DOI: 10.1016/j.jcpa.2020.09.005
Abstrakt: Uraemic encephalopathy (UE) is rarely associated with acute kidney injury or chronic kidney disease in domestic animals, and we now report the first case in a cat. The animal presented with hypothermia, apathy, lethargy, depression, severe dehydration, uraemic breath, elevated serum urea nitrogen and creatine concentrations, and eventual seizures and coma prior to death. Gross necropsy findings included severe bilateral renal scarring, ulcerative stomatitis and glossitis, and uraemic gastropathy. Microscopic lesions of diffuse interstitial fibrosis, multifocal mineralization and lymphoplasmacytic interstitial nephritis were seen in the kidneys. There was symmetrical, bilateral spongy vacuolation of the white matter of the basal nuclei and cerebellum and Alzheimer type II astrocytes in the cerebral cortex and hippocampus. Glial fibrillary acid protein immunolabelling was absent or faint in astrocytes of the cerebral grey matter. UE should be included in the differential diagnosis in animals with chronic kidney disease and neurological signs.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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