Visual field outcomes in children treated for neurofibromatosis type 1-associated optic pathway gliomas: a multicenter retrospective study.

Autor: Heidary G; Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address: gena.heidary@childrens.harvard.edu., Fisher MJ; Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania., Liu GT; Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania., Ferner RE; Guy's and St. Thomas' Hospital, London, United Kingdom., Gutmann DH; St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, Missouri., Listernick RH; Ann & Robert H. Lurie Children's Hospital of Chicago, Feinberg School of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Kapur K; Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Loguidice M; Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania., Ardern-Holmes SL; The Children's Hospital at Westmead, Sydney, Australia., Avery RA; Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania; Children's National Medical Center, Washington, District of Columbia., Hammond C; Guy's and St. Thomas' Hospital, London, United Kingdom., Hoffman RO; Moran Eye Center, University of Utah, Salt Lake City, Utah., Hummel TR; Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio., Kuo A; Moran Eye Center, University of Utah, Salt Lake City, Utah., Reginald A; The Hospital for Sick Children, Toronto, Ontario, Canada., Ullrich NJ; Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
Jazyk: angličtina
Zdroj: Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus [J AAPOS] 2020 Dec; Vol. 24 (6), pp. 349.e1-349.e5. Date of Electronic Publication: 2020 Nov 20.
DOI: 10.1016/j.jaapos.2020.07.013
Abstrakt: Background: Optic pathway gliomas associated with neurofibromatosis type 1 (NF1-OPGs) may adversely affect visual acuity, but data regarding visual field (VF) outcomes after treatment in children are limited. The purpose of this study was to investigate the effects of NF1-OPGs on VF function in a large cohort of children after treatment with chemotherapy.
Methods: We performed a retrospective, international, multicenter study of VF outcomes in patients treated with chemotherapy for NF1-OPGs.
Results: A total of 25 participants underwent VF testing using formal perimetric techniques. At the end of treatment, 19 participants (76%) had persistent VF deficits. Formal VF testing was available for 16 participants (64%) at initiation and completion of treatment. Of the 16 children who underwent VF testing at initiation and completion of treatment, 7 (44%) showed stability of VF changes, 3 (19%) showed improvement of VF function, and 6 (38%) had worsening of VFs. Improvement or worsening of VF outcome did not always correlate with visual acuity outcome. Posterior tumor location involving the optic tracts and radiations was associated with more frequent and more profound VF defects.
Conclusions: In our study cohort, children undergoing initial chemotherapy for NF1-OPGs had a high prevalence of VF loss, which could be independent of visual acuity loss. A larger, prospective study is necessary to fully determine the prevalence of VF loss and the effects of chemotherapy on VF outcomes in children with NF1-OPGs.
(Copyright © 2020 American Association for Pediatric Ophthalmology and Strabismus. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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