Elevated interleukin 31 serum levels in hemodialysis patients are associated with uremic pruritus.

Autor: Oweis AO; Department of Internal Medicine, Nephrology Division, Jordan University of Science and Technology, Irbid, Jordan. Electronic address: aooweis@just.edu.jo., Al-Qarqaz F; Department of Internal Medicine, Dermatology Division, Jordan University of Science and Technology, Irbid, Jordan., Bodoor K; Department of Applied Biology, Jordan University of Science and Technology, Irbid, Jordan., Heis L; Department of Internal Medicine, Dermatology Division, Jordan University of Science and Technology, Irbid, Jordan., Alfaqih MA; Department of Physiology and Biochemistry, Jordan University of Science and Technology, Irbid, Jordan., Almomani R; Department of Medical Laboratory Sciences, Jordan University of Science and Technology, Irbid, Jordan., Obeidat MA; Department of Internal Medicine, Nephrology Division, Jordan University of Science and Technology, Irbid, Jordan., Alshelleh SA; Department of Internal Medicine, Nephrology Division, The University of Jordan, Amman, Jordan.
Jazyk: angličtina
Zdroj: Cytokine [Cytokine] 2021 Feb; Vol. 138, pp. 155369. Date of Electronic Publication: 2020 Nov 19.
DOI: 10.1016/j.cyto.2020.155369
Abstrakt: Introduction: Uremic pruritus is a multifactorial devastating complication of renal failure, which has a significant negative impact on patients' quality of life including medical, psychological, as well as social aspects. It is also associated with an increased mortality in dialysis patients.
Methods: A cross sectional study evaluating the traditional risk factors for uremic pruritus (UP) - using pruritus grading system (PGS) and visual analogue scale (VAS) - as well as measuring the serum levels of different inflammatory cytokines (ILs 13, 31 and 33) in chronic hemodialysis and healthy controls, in a tertiary referral hospital.
Results: 65 hemodialysis (HD) patients and 49 heathy controls were enrolled in the study. The mean age for the HD patients was 43.4 years (SD ± 21.3), and 31.5 years (SD ± 11.1) for the control group. The most common cause for End Stage Renal Disease (ESRD) was diabetes mellitus (DM) 27.7%. The mean PGS score in HD patients was 5.92 (SD ± 2.9); 50% had mild itch, 43.8% moderate itch and 6.2% had severe itch. The mean serum levels for IL-13 was 8674.3 pg/ml (SD ± 4353.9), serum levels of IL-31 were 150.7 pg/ml (SD ± 178.2) and for IL-33 it was 42850.5 pg/ml (SD ± 11370.7) in hemodialysis patients; in comparison to serum levels of 7913.4 pg/ml (SD ± 3454.1), 67.1 pg/ml (SD ± 71.9) and 44875.9 pg/ml (SD ± 12114.6), respectively in the control group. IL-31 level was significantly higher in HD patients than in the control group (P = 0.0001), while the difference in the levels of IL-13 and IL-33 between the two groups were not statistically significant (P = 0.41 and 0.18, respectively). IL-13 had a statistically significant relationship with the itch score (P = 0.014) and the severity of itch (P = 0.03), while IL-31 and IL-33 were not statistically significant.
Conclusion: UP is a complex and multifactorial problem. In patients with UP the high levels of IL-31 indicates a possible role in pathogenesis. IL-13 serum level on the other hand may be related to the severity of itch in these patients. Optimizing dialysis and targeting these cytokines may provide a potential therapeutic option especially in refractory UP. Further studies addressing these cytokines and their levels in response to various treatments may provide additional information on UP.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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